Saponins-mediated potentiation of cisplatin accumulation and cytotoxicity in human colon cancer cells

被引：33

作者：

Gaidi, G

Correia, M

Chauffert, B

Beltramo, JL

Wagner, H

Lacaille-Dubois, MA

机构：

[1] Univ Bourgogne, Fac Pharm, Lab Pharmacognosie, Unite MIB, F-21079 Dijon, France

[2] Univ Bourgogne, Fac Med, INSERM, U517, F-21079 Dijon, France

[3] Univ Bourgogne, Fac Pharm, Chim Analyt Lab, F-21079 Dijon, France

[4] Univ Munich, Pharma Res Ctr, Munich, Germany

来源：

PLANTA MEDICA | 2002年 / 68卷 / 01期

关键词：

D O I：

10.1055/s-2002-19873

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The triterpene saponins jenisseensosides A, B, C, D were found to increase the accumulation and cytotoxicity of the anticancer agent cisplatin in human colon tumor cells. These compounds are glycosides of quillaic acid whose fucose residue was acylated by a trans- or cis-p methoxycinnamic acid. In contrarst, other saponins derivatives without this acyl moiety were not found to potentiate the accumulation and cytotoxicity of cisplatin. These results suggested the importance of the acyl moiety for activity.

引用

页码：70 / 72

页数：3

共 12 条

[1] The membrane-permeabilizing effect of avenacin A-1 involves the reorganization of bilayer cholesterol [J].