A comparative perspective on lipid storage in animals

被引：118

作者：

Birsoy, Kivanc ^{[1
]}

Festuccia, William T. ^{[2
]}

Laplante, Mathieu ^{[3
]}

机构：

[1] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

[2] Univ Sao Paulo, Inst Biomed Sci, BR-05508000 Sao Paulo, Brazil

[3] Univ Laval, Fac Med, CRIUCPQ, Ste Foy, PQ G1V 4G5, Canada

来源：

JOURNAL OF CELL SCIENCE | 2013年 / 126卷 / 07期

基金：

巴西圣保罗研究基金会; 加拿大自然科学与工程研究理事会;

关键词：

Adipocyte stem cell; Adipose tissue; Invertebrate fat; Lipid storage; Nutrients; ACTIVATED RECEPTOR-GAMMA; YEAST SACCHAROMYCES-CEREVISIAE; SEIP CONGENITAL LIPODYSTROPHY; GATA TRANSCRIPTION FACTORS; ADIPOSE-TISSUE HYPOXIA; DIET-INDUCED OBESITY; ADIPOCYTE DIFFERENTIATION; FAT STORAGE; INSULIN-RESISTANCE; FOOD-INTAKE;

D O I：

10.1242/jcs.104992

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Lipid storage is an evolutionary conserved process that exists in all organisms from simple prokaryotes to humans. In Metazoa, long-term lipid accumulation is restricted to specialized cell types, while a dedicated tissue for lipid storage (adipose tissue) exists only in vertebrates. Excessive lipid accumulation is associated with serious health complications including insulin resistance, type 2 diabetes, cardiovascular diseases and cancer. Thus, significant advances have been made over the last decades to dissect out the molecular and cellular mechanisms involved in adipose tissue formation and maintenance. Our current understanding of adipose tissue development comes from in vitro cell culture and mouse models, as well as recent approaches to study lipid storage in genetically tractable lower organisms. This Commentary gives a comparative insight into lipid storage in uni- and multi-cellular organisms with a particular emphasis on vertebrate adipose tissue. We also highlight the molecular mechanisms and nutritional signals that regulate the formation of mammalian adipose tissue.

引用

页码：1541 / 1552

页数：12

共 204 条

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