Synthesis of Polypeptides by Ring-Opening Polymerization of α-Amino Acid N-Carboxyanhydrides

被引：173

作者：

Cheng, Jianjun ^{[1
]}

Deming, Timothy J. ^{[2
]}

机构：

[1] Univ Illinois, Dept Mat Sci & Engn, Champaign, IL 61801 USA

[2] Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA

来源：

PEPTIDE-BASED MATERIALS | 2012年 / 310卷

关键词：

Amino acid; Block copolymer; N-Carboxyanhydride; Polymerization; Polypeptide; BENZYL-L-GLUTAMATE; LIVING POLYMERIZATION; BLOCK COPOLYPEPTIDES; NCA POLYMERIZATION; DIBLOCK COPOLYMERS; FACILE SYNTHESIS; L-PHENYLALANINE; SOLID-STATE; L-ALANINE; ANHYDRIDES;

D O I：

10.1007/128_2011_173

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This chapter summarizes methods for the synthesis of polypeptides by ring-opening polymerization. Traditional and recently improved methods used to polymerize alpha-amino acid N-carboxyanhydrides (NCAs) for the synthesis of homo-polypeptides are described. Use of these methods and strategies for the preparation of block copolypeptides and side-chain-functionalized polypeptides are also presented, as well as an analysis of the synthetic scope of different approaches. Finally, issues relating to obtaining highly functional polypeptides in pure form are detailed.

引用

页码：1 / 26

页数：26

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