Roles of Kruppel-like factor 4 in normal homeostasis, cancer and stem cells

被引：161

作者：

Evans, Paul M. ^{[1
]}

Liu, Chunming ^{[1
]}

机构：

[1] Univ Texas Med Branch, Dept Biochem & Mol Biol, Sealy Ctr Canc Cell Biol, Galveston, TX 77555 USA

来源：

ACTA BIOCHIMICA ET BIOPHYSICA SINICA | 2008年 / 40卷 / 07期

关键词：

Kruppel-like factor 4; colorectal cancer; stem cell;

D O I：

10.1111/j.1745-7270.2008.00439.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Kruppel-like factor 4 (KLF4) is a zinc finger-type transcription factor expressed in a variety of tissues, including the epithelium of the intestine and the skin, and it plays an important role in differentiation and cell cycle arrest. Depending on the gene targeted, KLF4 can both activate and repress transcription. Moreover, in certain cellular contexts, KLF4 can function as a tumor suppressor or an oncogene. Finally, KLF4 is important in reprogramming differentiated fibroblasts into inducible pluripotent stem cells, which highly resemble embryonic stem cells. This review summarizes what is known about the diverse functions of KLF4 as well as their molecular mechanisms.

引用

页码：554 / 564

页数：11

共 123 条

[1] Positive- and negative-acting Kruppel-like transcription factors bind a transforming growth factor β control element required for expression of the smooth muscle cell differentiation marker SM22α in vivo [J].

Adam, PJ ;

Regan, CP ;

Hautmann, MB ;

Owens, GK .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (48) :37798-37806

[2] Tip60 functions as a potential corepressor of KLF4 in regulation of HDC promoter activity [J].

Ai, Walden ;

Zheng, Hai ;

Yang, Xiangdong ;

Liu, Ying ;

Wang, Timothy C. .

NUCLEIC ACIDS RESEARCH, 2007, 35 (18) :6137-6149

[3] Kruppel-like factor 4 (KLF4) represses histidine decarboxylase gene expression through an upstream Sp1 site and downstream gastrin responsive elements [J].

Ai, WD ;

Liu, Y ;

Langlois, M ;

Wang, TC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (10) :8684-8693

[4] Kruppel-like factor 4 is essential for inflammatory monocyte differentiation in vivo [J].

Alder, Jonathan K. ;

Georgantas, Robert W., III ;

Hildreth, Richard L. ;

Kaplan, Ian M. ;

Morisot, Sebastien ;

Yu, Xiaobing ;

McDevitt, Michael ;

Civin, Curt I. .

JOURNAL OF IMMUNOLOGY, 2008, 180 (08) :5645-5652

[5] ORNITHINE DECARBOXYLASE ACTIVITY IS CRITICAL FOR CELL-TRANSFORMATION [J].

AUVINEN, M ;

PAASINEN, A ;

ANDERSSON, LC ;

HOLTTA, E .

NATURE, 1992, 360 (6402) :355-358

[6] β-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/EphrinB [J].

Batlle, E ;

Henderson, JT ;

Beghtel, H ;

van den Born, MMW ;

Sancho, E ;

Huls, G ;

Meeldijk, J ;

Robertson, J ;

van de Wetering, M ;

Pawson, T ;

Clevers, H .

CELL, 2002, 111 (02) :251-263

[7] Lung cancers detected by screening with spiral computed tomography have a malignant phenotype when analyzed by cDNA Mmicroarray [J].

Bianchi, F ;

Hu, JT ;

Pelosi, G ;

Cirincione, R ;

Ferguson, M ;

Ratcliffe, C ;

Di Fiore, PP ;

Gatter, K ;

Pezzella, F ;

Pastorino, U .

CLINICAL CANCER RESEARCH, 2004, 10 (18) :6023-6028

[8] Transcriptional regulation of adipogenesis by KLF4 [J].

Birsoy, Kivanc ;

Chen, Zhu ;

Friedman, Jeffrey .

CELL METABOLISM, 2008, 7 (04) :339-347

[9] Sp1 and kruppel-like factor family of transcription factors in cell growth regulation and cancer [J].

Black, AR ;

Black, JD ;

Azizkhan-Clifford, J .

JOURNAL OF CELLULAR PHYSIOLOGY, 2001, 188 (02) :143-160

[10] Activation of the human pregnancy-specific glycoprotein PSG-5 promoter by KLF4 and Sp1 [J].

Blanchon, L ;

Nores, R ;

Gallot, D ;

Marceau, G ;

Borel, V ;

Yang, VW ;

Bocco, JL ;

Lémery, D ;

Panzetta-Dutari, G ;

Sapin, V .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2006, 343 (03) :745-753

← 1 2 3 4 5 6 7 8 9 10 →