Rapidly growing mycobacterial bloodstream infections

被引：122

作者：

El Helou, Gilbert ^{[1
]}

Viola, George M. ^{[1
]}

Hachem, Ray ^{[1
]}

Han, Xiang Y. ^{[2
]}

Raad, Issam I. ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Infect Dis Infect Control & Employee Hlth, Unit 1460, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Lab Med, Unit 1460, Houston, TX 77030 USA

来源：

LANCET INFECTIOUS DISEASES | 2013年 / 13卷 / 02期

关键词：

RIBOSOMAL-RNA GENE; INTRINSIC MACROLIDE RESISTANCE; CATHETER-ASSOCIATED BACTEREMIA; CELL TRANSPLANT RECIPIENTS; NONTUBERCULOUS MYCOBACTERIA; PACEMAKER INFECTION; BIOFILM FORMATION; PSEUDO-OUTBREAK; MUCOGENICUM BACTEREMIA; ABSCESSUS INFECTION;

D O I：

10.1016/S1473-3099(12)70316-X

中图分类号：

R51 [传染病];

学科分类号：

100201 [内科学];

摘要：

About 20 species of rapidly growing mycobacteria species that are capable of infecting human beings and causing bloodstream infections have been identified. Many more of these species are being discovered worldwide, especially in resource-poor settings. These microorganisms have been known to cause outbreaks and pseudo-outbreaks. Although rapidly growing mycobacteria are not highly virulent or life threatening, they have a high predisposition to create biofilms and to colonise and infect intravascular catheters. Early detection and identification of specific species can help to estimate predictable antimicrobial susceptibility patterns. However, because susceptibility data originate from developed countries, studies in resource-poor settings urgently need to be done. The best outcome of cure without recurrence depends on a combination of at least 4 weeks of treatment with two or more active antimicrobial agents, plus removal of the intravascular catheter. We review and discuss the epidemiology, pathogenesis, diagnosis, management, and outcomes of rapidly growing mycobacterial bloodstream infections.

引用

页码：166 / 174

页数：9

共 118 条

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