共 40 条
Transmembrane Delivery of the Cell-Penetrating Peptide Conjugated Semiconductor Quantum Dots
被引:83
作者:

Chen, Bo
论文数: 0 引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Inst Chem, BNLMS, Key Lab Mol Nanostruct & Nanotechnol, Beijing 100080, Peoples R China
Chinese Acad Sci, Grad Sch, Beijing 100080, Peoples R China Chinese Acad Sci, Inst Chem, BNLMS, Key Lab Mol Nanostruct & Nanotechnol, Beijing 100080, Peoples R China

Liu, Qiaoling
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h-index: 0
机构:
Chinese Acad Sci, Inst Chem, BNLMS, Key Lab Mol Nanostruct & Nanotechnol, Beijing 100080, Peoples R China
Chinese Acad Sci, Grad Sch, Beijing 100080, Peoples R China Chinese Acad Sci, Inst Chem, BNLMS, Key Lab Mol Nanostruct & Nanotechnol, Beijing 100080, Peoples R China

Zhang, Yuliang
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h-index: 0
机构:
Chinese Acad Sci, Inst Chem, BNLMS, Key Lab Mol Nanostruct & Nanotechnol, Beijing 100080, Peoples R China Chinese Acad Sci, Inst Chem, BNLMS, Key Lab Mol Nanostruct & Nanotechnol, Beijing 100080, Peoples R China

Xu, Li
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h-index: 0
机构:
Chinese Acad Sci, Inst Chem, BNLMS, Key Lab Mol Nanostruct & Nanotechnol, Beijing 100080, Peoples R China Chinese Acad Sci, Inst Chem, BNLMS, Key Lab Mol Nanostruct & Nanotechnol, Beijing 100080, Peoples R China

Fang, Xiaohong
论文数: 0 引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Inst Chem, BNLMS, Key Lab Mol Nanostruct & Nanotechnol, Beijing 100080, Peoples R China Chinese Acad Sci, Inst Chem, BNLMS, Key Lab Mol Nanostruct & Nanotechnol, Beijing 100080, Peoples R China
机构:
[1] Chinese Acad Sci, Inst Chem, BNLMS, Key Lab Mol Nanostruct & Nanotechnol, Beijing 100080, Peoples R China
[2] Chinese Acad Sci, Grad Sch, Beijing 100080, Peoples R China
来源:
基金:
中国国家自然科学基金;
关键词:
D O I:
10.1021/la802048s
中图分类号:
O6 [化学];
学科分类号:
0703 ;
摘要:
Conjugation of the cell-penetrating peptide derived from the human immunodeficiency virus-1 transactivator protein (TAT) to semiconductor quantum dots (QDs) is an effective way to enhance transmembrane delivery of QDs for intracellular and molecular imaging. In this work, the internalization pathway of TAT-QDs was studied systematically in living cells. Cellular uptake of TAT-QDs, under different endocytosis-inhibiting conditions, was compared by fluorescence imaging and flow cytometry. The results suggest TAT-QDs internalize through lipid-raft-dependent macropinocytosis, which is different from that of FITC-labeled TAT. They also provide new information for better understanding of the TAT-mediated cell uptake mechanism.
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页码:11866 / 11871
页数:6
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共 40 条
- [1] A cell nanoinjector based on carbon nanotubes[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (20) : 8218 - 8222Chen, Xing论文数: 0 引用数: 0 h-index: 0机构: Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USAKis, Andras论文数: 0 引用数: 0 h-index: 0机构: Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USAZettl, A.论文数: 0 引用数: 0 h-index: 0机构: Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USABertozzi, Carolyn R.论文数: 0 引用数: 0 h-index: 0机构: Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA
- [2] Regulated portals of entry into the cell[J]. NATURE, 2003, 422 (6927) : 37 - 44Conner, SD论文数: 0 引用数: 0 h-index: 0机构: Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USASchmid, SL论文数: 0 引用数: 0 h-index: 0机构: Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA
- [3] Quantum dots protected with tiopronin: A new fluorescence system for cell-biology studies[J]. CHEMBIOCHEM, 2005, 6 (06) : 989 - 991de la Fuente, JM论文数: 0 引用数: 0 h-index: 0机构: Univ Glasgow, Ctr Cell Engn, Inst Biomed & Life Sci, Glasgow G12 8QQ, Lanark, ScotlandFandel, M论文数: 0 引用数: 0 h-index: 0机构: Univ Glasgow, Ctr Cell Engn, Inst Biomed & Life Sci, Glasgow G12 8QQ, Lanark, ScotlandBerry, CC论文数: 0 引用数: 0 h-index: 0机构: Univ Glasgow, Ctr Cell Engn, Inst Biomed & Life Sci, Glasgow G12 8QQ, Lanark, ScotlandRiehle, M论文数: 0 引用数: 0 h-index: 0机构: Univ Glasgow, Ctr Cell Engn, Inst Biomed & Life Sci, Glasgow G12 8QQ, Lanark, ScotlandCronin, L论文数: 0 引用数: 0 h-index: 0机构: Univ Glasgow, Ctr Cell Engn, Inst Biomed & Life Sci, Glasgow G12 8QQ, Lanark, ScotlandAitchison, G论文数: 0 引用数: 0 h-index: 0机构: Univ Glasgow, Ctr Cell Engn, Inst Biomed & Life Sci, Glasgow G12 8QQ, Lanark, ScotlandCurtis, ASG论文数: 0 引用数: 0 h-index: 0机构: Univ Glasgow, Ctr Cell Engn, Inst Biomed & Life Sci, Glasgow G12 8QQ, Lanark, Scotland
- [4] Self-assembled quantum dot-peptide bioconjugates for selective intracellular delivery[J]. BIOCONJUGATE CHEMISTRY, 2006, 17 (04) : 920 - 927Delehanty, James B.论文数: 0 引用数: 0 h-index: 0机构: USN, Res Lab, Ctr Biomol Sci & Engn, Washington, DC 20375 USAMedintz, Igor L.论文数: 0 引用数: 0 h-index: 0机构: USN, Res Lab, Ctr Biomol Sci & Engn, Washington, DC 20375 USAPons, Thomas论文数: 0 引用数: 0 h-index: 0机构: USN, Res Lab, Ctr Biomol Sci & Engn, Washington, DC 20375 USABrunel, Florence M.论文数: 0 引用数: 0 h-index: 0机构: USN, Res Lab, Ctr Biomol Sci & Engn, Washington, DC 20375 USADawson, Philip E.论文数: 0 引用数: 0 h-index: 0机构: USN, Res Lab, Ctr Biomol Sci & Engn, Washington, DC 20375 USAMattoussi, Hedi论文数: 0 引用数: 0 h-index: 0机构: USN, Res Lab, Ctr Biomol Sci & Engn, Washington, DC 20375 USA
- [5] Studies on the internalization mechanism of cationic cell-penetrating peptides[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (33) : 31192 - 31201Drin, G论文数: 0 引用数: 0 h-index: 0机构: Parc Sci Georges Besse, Synt Em, F-30000 Nimes, FranceCottin, S论文数: 0 引用数: 0 h-index: 0机构: Parc Sci Georges Besse, Synt Em, F-30000 Nimes, FranceBlanc, E论文数: 0 引用数: 0 h-index: 0机构: Parc Sci Georges Besse, Synt Em, F-30000 Nimes, FranceRees, AR论文数: 0 引用数: 0 h-index: 0机构: Parc Sci Georges Besse, Synt Em, F-30000 Nimes, FranceTemsamani, J论文数: 0 引用数: 0 h-index: 0机构: Parc Sci Georges Besse, Synt Em, F-30000 Nimes, France Parc Sci Georges Besse, Synt Em, F-30000 Nimes, France
- [6] Tapping mode atomic force microscopy for nanoparticle sizing: Tip-sample interaction effects[J]. NANO LETTERS, 2002, 2 (09) : 945 - 950Ebenstein, Y论文数: 0 引用数: 0 h-index: 0机构: Hebrew Univ Jerusalem, Farkas Ctr Light Induced Proc, Inst Chem, IL-91904 Jerusalem, IsraelNahum, E论文数: 0 引用数: 0 h-index: 0机构: Hebrew Univ Jerusalem, Farkas Ctr Light Induced Proc, Inst Chem, IL-91904 Jerusalem, IsraelBanin, U论文数: 0 引用数: 0 h-index: 0机构: Hebrew Univ Jerusalem, Farkas Ctr Light Induced Proc, Inst Chem, IL-91904 Jerusalem, Israel Hebrew Univ Jerusalem, Farkas Ctr Light Induced Proc, Inst Chem, IL-91904 Jerusalem, Israel
- [7] Protein transduction domain of HIV-1 Tat protein promotes efficient delivery of DNA into mammalian cells[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (28) : 26204 - 26210Eguchi, A论文数: 0 引用数: 0 h-index: 0机构: Osaka Univ, Dept Neurovirol, Res Inst Microbial Dis, Suita, Osaka 5650871, JapanAkuta, T论文数: 0 引用数: 0 h-index: 0机构: Osaka Univ, Dept Neurovirol, Res Inst Microbial Dis, Suita, Osaka 5650871, JapanOkuyama, H论文数: 0 引用数: 0 h-index: 0机构: Osaka Univ, Dept Neurovirol, Res Inst Microbial Dis, Suita, Osaka 5650871, JapanSenda, T论文数: 0 引用数: 0 h-index: 0机构: Osaka Univ, Dept Neurovirol, Res Inst Microbial Dis, Suita, Osaka 5650871, JapanYokoi, H论文数: 0 引用数: 0 h-index: 0机构: Osaka Univ, Dept Neurovirol, Res Inst Microbial Dis, Suita, Osaka 5650871, JapanInokuchi, H论文数: 0 引用数: 0 h-index: 0机构: Osaka Univ, Dept Neurovirol, Res Inst Microbial Dis, Suita, Osaka 5650871, JapanFujita, S论文数: 0 引用数: 0 h-index: 0机构: Osaka Univ, Dept Neurovirol, Res Inst Microbial Dis, Suita, Osaka 5650871, JapanHayakawa, T论文数: 0 引用数: 0 h-index: 0机构: Osaka Univ, Dept Neurovirol, Res Inst Microbial Dis, Suita, Osaka 5650871, Japan论文数: 引用数: h-index:机构:论文数: 引用数: h-index:机构:Nakanishi, M论文数: 0 引用数: 0 h-index: 0机构: Osaka Univ, Dept Neurovirol, Res Inst Microbial Dis, Suita, Osaka 5650871, Japan
- [8] Caveolae-mediated internalization of extracellular HIV-1 tat fusion proteins visualized in real time[J]. MOLECULAR THERAPY, 2003, 8 (02) : 284 - 294Ferrari, A论文数: 0 引用数: 0 h-index: 0机构: INFM, NEST, I-56126 Pisa, ItalyPellegrini, V论文数: 0 引用数: 0 h-index: 0机构: INFM, NEST, I-56126 Pisa, ItalyArcangeli, C论文数: 0 引用数: 0 h-index: 0机构: INFM, NEST, I-56126 Pisa, ItalyFittipaldi, A论文数: 0 引用数: 0 h-index: 0机构: INFM, NEST, I-56126 Pisa, ItalyGiacca, M论文数: 0 引用数: 0 h-index: 0机构: INFM, NEST, I-56126 Pisa, ItalyBeltram, F论文数: 0 引用数: 0 h-index: 0机构: INFM, NEST, I-56126 Pisa, Italy
- [9] Break on through to the other side - Biophysics and cell biology shed light on cell-penetrating peptides[J]. CHEMBIOCHEM, 2005, 6 (12) : 2126 - 2142Fischer, R论文数: 0 引用数: 0 h-index: 0机构: Univ Tubingen, Inst Cell Biol, D-72076 Tubingen, Germany Univ Tubingen, Inst Cell Biol, D-72076 Tubingen, GermanyFotin-Mleczek, M论文数: 0 引用数: 0 h-index: 0机构: Univ Tubingen, Inst Cell Biol, D-72076 Tubingen, Germany Univ Tubingen, Inst Cell Biol, D-72076 Tubingen, GermanyHufnagel, H论文数: 0 引用数: 0 h-index: 0机构: Univ Tubingen, Inst Cell Biol, D-72076 Tubingen, Germany Univ Tubingen, Inst Cell Biol, D-72076 Tubingen, GermanyBrock, R论文数: 0 引用数: 0 h-index: 0机构: Univ Tubingen, Inst Cell Biol, D-72076 Tubingen, Germany Univ Tubingen, Inst Cell Biol, D-72076 Tubingen, Germany
- [10] In vivo cancer targeting and imaging with semiconductor quantum dots[J]. NATURE BIOTECHNOLOGY, 2004, 22 (08) : 969 - 976Gao, XH论文数: 0 引用数: 0 h-index: 0机构: Emory Univ, Dept Urol, Atlanta, GA 30322 USACui, YY论文数: 0 引用数: 0 h-index: 0机构: Emory Univ, Dept Urol, Atlanta, GA 30322 USALevenson, RM论文数: 0 引用数: 0 h-index: 0机构: Emory Univ, Dept Urol, Atlanta, GA 30322 USA论文数: 引用数: h-index:机构:Nie, SM论文数: 0 引用数: 0 h-index: 0机构: Emory Univ, Dept Urol, Atlanta, GA 30322 USA