Hip bone density predicts breast cancer risk independently of gail score - Results from the women's health initiative

被引：57

作者：

Chen, Zhao ^{[1
]}

Arendell, Leslie ^{[1
]}

Aickin, Mikel ^{[2
]}

Cauley, Jane ^{[3
]}

Lewis, Cora E. ^{[4
,28
]}

Chlebowski, Rowan ^{[5
,18
]}

Nabel, Elizabeth ^{[6
]}

Rossouw, Jacques ^{[6
]}

Ludlam, Shari ^{[6
]}

Pottern, Linda ^{[6
]}

McGowan, Joan ^{[6
]}

Ford, Leslie ^{[6
]}

Geller, Nancy ^{[6
]}

Prentice, Ross ^{[7
]}

Anderson, Garnet ^{[7
]}

LaCroix, Andrea ^{[7
]}

Kooperberg, Charles L. ^{[7
]}

Patterson, Ruth E. ^{[7
]}

McTiernan, Anne ^{[7
]}

Shumaker, Sally ^{[8
]}

Stein, Evan ^{[9
]}

Cummings, Steven ^{[10
]}

Wassertheil-Smoller, Sylvia ^{[11
]}

Hays, Jennifer ^{[12
]}

Manson, Joann ^{[13
]}

Assaf, Annlouise R. ^{[14
]}

Phillips, Lawrence ^{[15
]}

Beresford, Shirley ^{[16
]}

Hsia, Judith ^{[17
]}

Chlebowski, Rowan ^{[5
,18
]}

Whitlock, Evelyn ^{[19
]}

Caan, Bette ^{[20
]}

Howard, Barbara V. ^{[22
]}

Van Horn, Linda ^{[23
]}

Black, Henry ^{[24
]}

Stefanick, Marcia L. ^{[25
]}

Lane, Dorothy ^{[26
]}

Jackson, Rebecca ^{[27
]}

Lewis, Cora E. ^{[4
,28
]}

Bassford, Tamsen ^{[29
]}

Wactawski-Wende, Jean ^{[30
]}

Robbins, John ^{[31
]}

Hubbell, F. Allan ^{[32
]}

Judd, Howard ^{[33
]}

Langer, Robert D. ^{[34
]}

Gass, Margery ^{[35
]}

Limacher, Marian ^{[36
]}

Curb, David ^{[37
]}

Wallace, Robert ^{[38
]}

Ockene, Judith ^{[39
]}

机构：

[1] Univ Arizona, Coll Publ Hlth, Div Epidemiol & Biostat, Tucson, AZ 85721 USA

[2] Univ Arizona, Dept Family & Community Med, Tucson, AZ USA

[3] Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA 15261 USA

[4] Univ Alabama, Sch Med, Div Prevent Med, Birmingham, AL USA

[5] Univ Calif Los Angeles, Med Ctr LABioMed, Los Angeles Biomed Res Inst Harbor, Torrance, CA USA

[6] NHLBI, Program Off, Bethesda, MD 20892 USA

[7] Fred Hutchinson Canc Res Ctr, Clin Coordinating Ctr, Seattle, WA 98104 USA

[8] Wake Forest Univ, Bowman Gray Sch Med, Winston Salem, NC USA

[9] Med Res Labs, Highland Hts, KY USA

[10] Univ Calif San Francisco, San Francisco, CA 94143 USA

[11] Albert Einstein Coll Med, Ctr Clin, Bronx, NY 10467 USA

[12] Baylor Coll Med, Houston, TX 77030 USA

[13] Harvard Univ, Sch Med, Womens Hosp, Boston, MA USA

[14] Brown Univ, Providence, RI 02912 USA

[15] Emory Univ, Atlanta, GA 30322 USA

[16] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA

[17] George Washington Univ, Med Ctr, Washington, DC 20037 USA

[18] Harbor Univ Calif Los Angeles, Med Ctr, Los Angeles Biomed Res Inst, Torrance, CA 90509 USA

[19] Kaiser Permanente Ctr Hlth Res, Portland, OR USA

[20] Kaiser Permanente, Div Res, Oakland, CA USA

[21] Med Coll Wisconsin, Milwaukee, WI 53226 USA

[22] Howard Univ, MedStar Res Inst, Washington, DC 20059 USA

[23] Northwestern Univ, Chicago, IL 60611 USA

[24] Rush Presbyterian St Lukes Med Ctr, Chicago, IL 60612 USA

[25] Stanford Prevent Res Ctr, Stanford, CA USA

[26] SUNY Stony Brook, Stony Brook, NY 11794 USA

[27] Ohio State Univ, Columbus, OH 43210 USA

[28] Univ Alabama, Birmingham, AL USA

[29] Univ Arizona, Tucson, AZ USA

[30] SUNY Coll Buffalo, Buffalo, NY 14222 USA

[31] Univ Calif Davis, Sacramento, CA 95817 USA

[32] Univ Calif Irvine, Irvine, CA USA

[33] Univ Calif Los Angeles, Los Angeles, CA USA

[34] Univ Calif San Diego, La Jolla, CA 92093 USA

[35] Univ Cincinnati, Cincinnati, OH USA

[36] Univ Florida, Jacksonville, FL USA

[37] Univ Hawaii, Honolulu, HI 96822 USA

[38] Univ Iowa, Iowa City, IA USA

[39] Univ Massachusetts, Fallon Clin, Worcester, MA 01605 USA

[40] Univ Med & Dent New Jersey, Newark, NJ 07103 USA

[41] Univ Miami, Miami, FL USA

[42] Univ Minnesota, Minneapolis, MN USA

[43] Univ Nevada, Reno, NV 89557 USA

[44] Univ N Carolina, Chapel Hill, NC USA

[45] Univ Pittsburgh, Pittsburgh, PA USA

[46] Univ Tennessee, Memphis, TN USA

[47] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA

[48] Univ Wisconsin, Madison, WI USA

[49] Wayne State Univ, Sch Med, Hutzel Hosp, Detroit, MI USA

来源：

CANCER | 2008年 / 113卷 / 05期

关键词：

breast cancer; postmenopausal women; Gail score; bone mineral density; Women's Health Initiative; receiver operator characteristic;

D O I：

10.1002/cncr.23674

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

BACKGROUND. The Gail model has been commonly used to estimate a woman's risk of breast cancer within a certain time period. High bone mineral density (BNID) is also a significant risk factor For breast cancer, but it appears to play no role in the Gail model. The objective of the current: study was to investigate whether hip BMD predicts postmenopausal breast cancer risk independently of the Gail score. METHODS. In this prospective Study, 9941 postmenopausal women who had a baseline hip BMD and Gail score from the Women's Health Initiative were included in the analysis. Their average age %vas 63.0 +/- 7.4 years at baseline. RESULTS. After an average of 8.43 years of follow-Lip, 327 incident breast cancer cases were reported and adjudicated. In a multivariate Cox proportional hazards model, the hazards ratios (95% confidence interval [95% CI]) for incident breast cancer were 1.35 (95% Cl, 1.05-1.73) for high Gail score (>= 1.67%) and 1.25 (95% Cl, 1.11-1.40) for each unit of increase in the total hip BMD T-score. Restricting the analysis to women with both BMD and a Gail score above the median, a sharp increase in incident breast cancer for women with the highest BNID and Gail scores was found (P <.05). CONCLUSIONS. The contribution of BMD to the prediction of incident postmenopausal breast cancer across the entire population was found to be independent of the Gail score. However, among women with both high BMD and a high Gail score, there appears to be an interaction between these 2 factors. These findings suggest that BMD and Gail score may be used together to better quantify the risk of breast cancer.

引用

页码：907 / 915

页数：9

共 21 条

[1]

Implementation of the Women's Health Initiative Study Design [J].

Anderson, GL ;

Manson, J ;

Wallace, R ;

Lund, B ;

Hall, D ;

Davis, S ;

Shumaker, S ;

Wang, CY ;

Stein, E ;

Prentice, RL .

ANNALS OF EPIDEMIOLOGY, 2003, 13 (09) :S5-S17

[2]

Bone mineral density and endogenous hormones and risk of breast cancer in postmenopausal women (United states) [J].

Buist, DSM ;

LaCroix, AZ ;

Barlow, WE ;

White, E ;

Cauley, JA ;

Bauer, DC ;

Weiss, NS .

CANCER CAUSES & CONTROL, 2001, 12 (03) :213-222

[3]

Bone mineral density and breast cancer risk in postmenopausal women [J].

Buist, DSM ;

LaCroix, AZ ;

Barlow, WE ;

White, E ;

Weiss, NS .

JOURNAL OF CLINICAL EPIDEMIOLOGY, 2001, 54 (04) :417-422

[4]

Bone mineral density and risk of breast cancer in older women - The study of osteoporotic fractures [J].

Cauley, JA ;

Lucas, FL ;

Kuller, LH ;

Vogt, MT ;

Browner, WS ;

Cummings, SR .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1996, 276 (17) :1404-1408

[5]

Projecting absolute invasive breast cancer risk in white women with a model that includes mammographic density [J].

Chen, Jinbo ;

Pee, David ;

Ayyagari, Rajeev ;

Graubard, Barry ;

Schairer, Catherine ;

Byrne, Celia ;

Benichou, Jacques ;

Gail, Mitchell H. .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2006, 98 (17) :1215-1226

[6]

American Society of Clinical Oncology technology assessment of pharmacologic interventions for breast cancer risk reduction including tamoxifen, raloxifene, and aromatase inhibition [J].

Chlebowski, RT ;

Col, N ;

Winer, EP ;

Collyar, DE ;

Cummings, SR ;

Vogel, VG ;

Burstein, HJ ;

Eisen, A ;

Lipkus, I ;

Pfister, DG .

JOURNAL OF CLINICAL ONCOLOGY, 2002, 20 (15) :3328-3343

[7]

Validation studies for models projecting the risk of invasive and total breast cancer incidence [J].

Costantino, JP ;

Gail, MH ;

Pee, D ;

Anderson, S ;

Redmond, CK ;

Benichou, J ;

Wieand, HS .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1999, 91 (18) :1541-1548

[8]

Cancer risk prediction models: A workshop on development, evaluation, and application [J].

Freedman, AN ;

Seminara, D ;

Gail, MH ;

Hartge, P ;

Colditz, GA ;

Ballard-Barbash, R ;

Pfeiffer, RM .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2005, 97 (10) :715-723

[9]

PROJECTING INDIVIDUALIZED PROBABILITIES OF DEVELOPING BREAST-CANCER FOR WHITE FEMALES WHO ARE BEING EXAMINED ANNUALLY [J].

GAIL, MH ;

BRINTON, LA ;

BYAR, DP ;

CORLE, DK ;

GREEN, SB ;

SCHAIRER, C ;

MULVIHILL, JJ .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1989, 81 (24) :1879-1886

[10]

The Women's Health Initiative recruitment methods and results [J].

Hays, J ;

Hunt, JR ;

Hubbell, FA ;

Anderson, GL ;

Limacher, M ;

Allen, C ;

Rossouw, JE .

ANNALS OF EPIDEMIOLOGY, 2003, 13 (09) :S18-S77

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