Localized proton MR spectroscopic detection of nonketotic hyperglycinemia in an infant

被引：17

作者：

Choi, CG ^{[1
]}

Lee, HK ^{[1
]}

Yoon, JH ^{[1
]}

机构：

[1] Univ Ulsan, Asan Med Ctr,Coll Med, Dept Radiol, Songpa Gu, Seoul 138736, South Korea

来源：

KOREAN JOURNAL OF RADIOLOGY | 2001年 / 2卷 / 04期

关键词：

brain; MR spectroscopy; metabolism;

D O I：

10.3348/kjr.2001.2.4.239

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Nonketotic hyperglycinemia (NKH) is a rare metabolic brain disease caused by deficient activity of the glycine cleveage system. Localized proton MR spectroscopy (echo-time 166 msec), performed in an infant with the typical clinical and biochemical features of neonatal NKH, showed a markedly increased peak intensity at 3.55 ppm, which was assigned to glycine. Serial proton MR spectrosocpic studies indicated that glycine/choline and glycine/total creatine ratios correlated closely with the patient's clinical course. Proton MR spectroscopy was useful for the non-invasive detection and monitoring of cerebral glycine levels in this infant with NKH.

引用

页码：239 / 242

页数：4

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