Thyroid transcription factor-1: A review

被引：140

作者：

Lau, SK

Luthringer, DJ

Eisen, RN

机构：

[1] Greenwich Hosp, Dept Pathol, Greenwich, CT 06830 USA

[2] Cedars Sinai Med Ctr, Dept Pathol, Los Angeles, CA 90048 USA

来源：

APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY | 2002年 / 10卷 / 02期

关键词：

TTF-1; immunohistochemistry; thyroid; lung;

D O I：

10.1097/00022744-200206000-00001

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Thyroid transcription factor-1 (TTF-1) is a 38-kd homeodomain containing DNA-binding protein originally identified in follicular cells of the thyroid and subsequently in pneumocytes. This review focuses on the utility of antisera in TTF-1 immunohistochemical staining in the diagnosis of neoplastic conditions. Based on published studies to date, anti-TTF-1 is a very useful reagent in distinguishing pulmonary adenocarcinoma from other primary carcinomas, identifying differentiated thyroid neoplasms, distinguishing mesothelioma from pulmonary adenocarcinoma, and distinguishing small cell carcinoma of the lung from Merkel cell carcinoma. It may also be useful in distinguishing neuroendocrine (NE) tumors of the lung from well-differentiated NE tumors from other sites, such as the intestine.

引用

页码：97 / 102

页数：6

共 54 条

[1] Thyroid transcription factor-1 is expressed in extrapulmonary small cell carcinomas but not in other extrapulmonary neuroendocrine tumors [J].