Functionalized carbon nanotubes as emerging nanovectors for the delivery of therapeutics

被引:410
作者
Klumpp, Cedric
Kostarelos, Kostas
Prato, Maurizio
Bianco, Alberto
机构
[1] CNRS, UPR 9021, Inst Mol & Cellular Biol, F-67084 Strasbourg, France
[2] Univ Trieste, Dept Pharmaceut Sci, I-34127 Trieste, Italy
[3] Univ London, Sch Pharm, Ctr Drug Delivery Res, London WC1N 1AX, England
来源
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 2006年 / 1758卷 / 03期
关键词
carbon nanotube; vector; vaccine; gene; drug delivery; peptide;
D O I
10.1016/j.bbamem.2005.10.008
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Functionalized carbon nanotubes (f-CNT) are emerging as a new family of nanovectors for the delivery of different types of therapeutic molecules. The application of CNT in the field of carrier-mediated delivery has become possible after the recent discovery of their capacity to penetrate into the cells. CNT can be loaded with active molecules by forming stable covalent bonds or supramolecular assemblies based on noncovalent interactions. Once the cargos are carried into various cells, tissues and organs they are able to express their biological function. In this review, we will describe the potential of f-CNT to deliver different types of therapeutic molecules. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码:404 / 412
页数:9
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