Perturbation of epigenetic status by toxicants

被引：45

作者：

Bombail, V ^{[1
]}

Moggs, JG ^{[1
]}

Orphanides, G ^{[1
]}

机构：

[1] Syngenta Cent Toxicol Lab, Macclesfield SK10 4TJ, Cheshire, England

来源：

TOXICOLOGY LETTERS | 2004年 / 149卷 / 1-3期

关键词：

epigenetic; DNA methylation; chromatin; non-genotoxic carcinogen; estrogen; nutrition;

D O I：

10.1016/j.toxlet.2004.01.003

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

It is becoming increasingly apparent that toxicant-induced changes in epigenetic status, particularly DNA methylation patterns, may play a role in some mechanisms of toxicity. Here, we discuss briefly the evidence that alterations in DNA methylation accompany, and may even promote, carcinogenesis induced by non-genotoxic chemicals. We also address recent findings indicating that the availability of dietary methyl donors can modulate DNA methylation levels and precipitate adverse effects. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：51 / 58

页数：8

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