The novel mitochondrial gene arrangement of the cattle tick, Boophilus microplus:: Fivefold tandem repetition of a coding region

被引:94
作者
Campbell, NJH [1 ]
Barker, SC
机构
[1] Univ Queensland, Dept Parasitol, Brisbane, Qld 4072, Australia
[2] Univ Queensland, Ctr Cellular & Mol Biol, Brisbane, Qld 4072, Australia
关键词
Boophilus microplus; mitochondrial genome; Ixodida; gene order; transfer RNA; tandem repeats;
D O I
10.1093/oxfordjournals.molbev.a026158
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We sequenced across all of the gene boundaries in the mitochondrial genome of the cattle tick, Boophilus microplus, to determine the arrangement of its genes. The mtDNA of B. microplus has a coding region, composed of tRNA(Glu) and 60 bp of the 3' end of ND1, that is repeated five times. Boophilus microplus is the first coelomate animal known to have more than two copies of a coding sequence. The mitochondrial genome of B, microplus has other unusual features, including (1) reduced T arms in tRNAs, (2) an AT bias in codon use, (3) two control regions that have evolved in concert, (4) three gene rearrangements, and (5) a stem-loop between tRNA(Gln) and tRNA(Phe). The short T arms and small control regions (CRs) of B. microplus and other ticks suggest strong selection for small genomes. Imprecise termination of replication beyond its origin, which can account for the evolution of tandem repeats of coding regions in other mitochondrial genomes, cannot explain the evolution of the fivefold repeated sequence in the mitochondrial genome of B. microplus. Instead, slipped-strand mispairing or recombination are the most plausible explanations for the evolution of these tandem repeats.
引用
收藏
页码:732 / 740
页数:9
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