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Nitric oxide and cell death

被引：359
作者：
Murphy, MP [1 ]
机构：
[1] Univ Otago, Dept Biochem, Dunedin, New Zealand
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS | 1999年 / 1411卷 / 2-3期
关键词：
nitric oxide; cell death; apoptosis; necrosis; neurodegeneration; ischemia-reperfusion injury; glutamate toxicity;
D O I：
10.1016/S0005-2728(99)00029-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Nitric oxide (NO) has several essential roles in mammals, but unregulated NO production can cause cell death through oxidative stress, disrupted energy metabolism DNA damage, activation of poly(ADP-ribose) polymerase, or dysregulation of cytosolic calcium. Such disturbances can lead to either apoptotic or necrotic cell death, depending on the severity and context of the damage. Here I review the mechanisms by which NO kills cells and discuss how NO thereby contributes to ischaemia-reperfusion injury and neurodegeneration. (C) 1999 Elsevier Science B.V. All rights reserved.
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收藏
页码：401 / 414
页数：14
相关论文
共 158 条
  • [1] GLUTAMATE-INDUCED NEURONAL DEATH - A SUCCESSION OF NECROSIS OR APOPTOSIS DEPENDING ON MITOCHONDRIAL-FUNCTION
    ANKARCRONA, M
    DYPBUKT, JM
    BONFOCO, E
    ZHIVOTOVSKY, B
    ORRENIUS, S
    LIPTON, SA
    NICOTERA, P
    [J]. NEURON, 1995, 15 (04) : 961 - 973
  • [2] Modulation of the mitochondrial permeability transition by nitric oxide
    Balakirev, MY
    Khramtsov, VV
    Zimmer, G
    [J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1997, 246 (03): : 710 - 718
  • [3] Glutathione protects astrocytes from peroxynitrite-mediated mitochondrial damage: Implications for neuronal astrocytic trafficking and neurodegeneration
    Barker, JE
    Bolanos, JP
    Land, JM
    Clark, JB
    Heales, SJR
    [J]. DEVELOPMENTAL NEUROSCIENCE, 1996, 18 (5-6) : 391 - 396
  • [4] IMMUNOCYTOCHEMICAL EVIDENCE FOR A MITOCHONDRIALLY LOCATED NITRIC-OXIDE SYNTHASE IN BRAIN AND LIVER
    BATES, TE
    LOESCH, A
    BURNSTOCK, G
    CLARK, JB
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1995, 213 (03) : 896 - 900
  • [5] APPARENT HYDROXYL RADICAL PRODUCTION BY PEROXYNITRITE - IMPLICATIONS FOR ENDOTHELIAL INJURY FROM NITRIC-OXIDE AND SUPEROXIDE
    BECKMAN, JS
    BECKMAN, TW
    CHEN, J
    MARSHALL, PA
    FREEMAN, BA
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (04) : 1620 - 1624
  • [6] Beckman JS, 1996, AM J PHYSIOL-CELL PH, V271, pC1424
  • [7] BECKMAN JS, 1994, ANN NY ACAD SCI, V738, P69
  • [8] ISCHEMIC-INJURY MEDIATOR
    BECKMAN, JS
    [J]. NATURE, 1990, 345 (6270) : 27 - 28
  • [9] BECKMAN JS, 1994, METHOD ENZYMOL, V233, P229, DOI DOI 10.1016/S0076-6879(94)33026-3
  • [10] Bolanos JP, 1997, J NEUROCHEM, V68, P2227
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