The use of dexamethasone in elderly patients with antidepressant-resistant depressive illness

被引：8

作者：

Bodani, M ^{[1
]}

Sheehan, B ^{[1
]}

Philpot, M ^{[1
]}

机构：

[1] Maudsley Hosp & Inst Psychiat, London SE5 8AZ, England

来源：

JOURNAL OF PSYCHOPHARMACOLOGY | 1999年 / 13卷 / 02期

关键词：

benefits; dexamethasone; elderly depression; mechanism of action; resistance; treatment;

D O I：

10.1177/026988119901300213

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Many depressed patients do not respond to first-line antidepressant treatment. Dexamethasone is a synthetic steroid which may have antidepressant properties. Its use in two elderly patients with resistant depression is reported. Both patients appeared to benefit from the treatment. The possible modes of action of this treatment, and its potential benefits to the elderly, are discussed.

引用

页码：196 / 197

页数：2

共 19 条

[1]

[Anonymous], 1972, CLIN PHARMACOL THER, V13, P694

[2]

ARANA GW, 1995, AM J PSYCHIAT, V152, P265

[3]

ARTIGAS F, 1994, ARCH GEN PSYCHIAT, V51, P248

[4]

BRODATY H, 1994, FUNCTIONAL DISORDERS

[5] LITHIUM INDUCES RAPID RELIEF OF DEPRESSION IN TRICYCLIC ANTI-DEPRESSANT DRUG NON-RESPONDERS [J].

DEMONTIGNY, C ;

GRUNBERG, F ;

MAYER, A ;

DESCHENES, JP .

BRITISH JOURNAL OF PSYCHIATRY, 1981, 138 (MAR) :252-256

[6] Dexamethasone augmentation in treatment-resistant depression [J].

Dinan, TG ;

Lavelle, E ;

Cooney, J ;

Burnett, F ;

Scott, L ;

Dash, A ;

Thakore, J ;

Berti, C .

ACTA PSYCHIATRICA SCANDINAVICA, 1997, 95 (01) :58-61

[7] MINI-MENTAL STATE - PRACTICAL METHOD FOR GRADING COGNITIVE STATE OF PATIENTS FOR CLINICIAN [J].

FOLSTEIN, MF ;

FOLSTEIN, SE ;

MCHUGH, PR .

JOURNAL OF PSYCHIATRIC RESEARCH, 1975, 12 (03) :189-198

[8] THE ADDITIONAL BENEFIT OF EXTENDING AN ANTIDEPRESSANT TRIAL PAST 7 WEEKS IN THE DEPRESSED ELDERLY [J].

GEORGOTAS, A ;

MCCUE, RE .

INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 1989, 4 (04) :191-195

[9] THE EFFECTS OF CORTISOL INFUSION UPON HORMONE-SECRETION FROM THE ANTERIOR-PITUITARY AND SUBJECTIVE MOOD IN DEPRESSIVE-ILLNESS AND IN CONTROLS [J].

GOODWIN, GM ;

MUIR, WJ ;

SECKL, JR ;

BENNIE, J ;

CARROLL, S ;

DICK, H ;

FINK, G .

JOURNAL OF AFFECTIVE DISORDERS, 1992, 26 (02) :73-84

[10]

JACOBY R, 1993, BRIT J PSYCHIAT, V162, P175

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