Honokiol, a natural therapeutic candidate, induces apoptosis and inhibits angiogenesis of ovarian tumor cells

被引：57

作者：

Li, Zhengyu ^{[1
]}

Liu, Yi ^{[1
]}

Zhao, Xia ^{[1
]}

Pan, Xiaoling ^{[1
]}

Yin, Rutie ^{[1
]}

Huang, Canhua ^{[2
]}

Chen, Lijuan ^{[2
]}

Wei, Yuquan ^{[2
]}

机构：

[1] Sichuan Univ, Dept Obstet & Gynecol, W China Hosp 2, Chengdu 610041, Peoples R China

[2] Sichuan Univ, State Key Lab Biotherapy Human Dis, W China Hosp, Chengdu 610041, Peoples R China

来源：

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY | 2008年 / 140卷 / 01期

关键词：

honokiol; ovarian tumor; apoptosis; angiogenesis;

D O I：

10.1016/j.ejogrb.2008.02.023

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objectives: To observe the anti-tumor activities of honokiol on human ovarian tumor in vitro and in vivo. Study design: Cells were treated with honokiol, and the effects on proliferation and apoptosis were examined by MTT, DNA ladder, Hoechst staining, and flow cytometry assays. Expression of Bcl-2 members and caspase-3 were assessed. Measurements of tumor volume and microvessel densities (MVDs) were performed. Results: Honokiol significantly inhibited proliferation and induced apoptosis, with alteration of Bcl-2 members and caspase-3. Administration of honokiol to tumor-bearing animals decreased MVD and resulted in inhibition of tumor growth. Conclusions: Honokiol could induce apoptosis and inhibit angiogenesis in vitro and in vivo, suggesting a novel and attractive therapeutic candidate for ovarian tumor treatment. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：95 / 102

页数：8

共 31 条

[1] Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-κB activation pathway [J].

Ahn, Kwang Seok ;

Sethi, Gautam ;

Shishodia, Shishir ;

Sung, Bokyung ;

Arbiser, Jack L. ;

Aggarwal, Bharat B. .

MOLECULAR CANCER RESEARCH, 2006, 4 (09) :621-633

[2] Epicatechin gallate-induced expression of NAG-1 is associated with growth inhibition and apoptosis in colon cancer cells [J].

Baek, SJ ;

Kim, JS ;

Jackson, FR ;

Eling, TE ;

McEntee, MF ;

Lee, SH .

CARCINOGENESIS, 2004, 25 (12) :2425-2432

[3] Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo [J].

Bai, XH ;

Cerimele, F ;

Ushio-Fukai, M ;

Waqas, M ;

Campbell, PM ;

Govindarajan, B ;

Der, CJ ;

Battle, T ;

Frank, DA ;

Ye, KQ ;

Murad, E ;

Dubiel, W ;

Soff, G ;

Arbiser, JL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (37) :35501-35507

[4]

BEOBYI L, 2006, FEBS LETT, V580, P5177

[5] Inhibition of telomerase activity and induction of apoptosis by curcurnin in K-562 cells [J].

Chakraborty, S ;

Ghosh, U ;

Bhattacharyya, NP ;

Bhattacharya, RK ;

Roy, M .

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2006, 596 (1-2) :81-90

[6]

Chen F, 2004, WORLD J GASTROENTERO, V10, P3459

[7] Interaction of CED-4 with CED-3 and CED-9: A molecular framework for cell death [J].

Chinnaiyan, AM ;

ORourke, K ;

Lane, BR ;

Dixit, VM .

SCIENCE, 1997, 275 (5303) :1122-1126

[8]

Chodorowska Grazyna, 2004, Ann Univ Mariae Curie Sklodowska Med, V59, P8

[9] Magnolol and honokiol enhance HL-60 human leukemia cell differentiation induced by 1,25-dihydroxyvitamin D3 and retinoic acid [J].

Fong, WF ;

Tse, AKW ;

Poon, KH ;

Wang, C .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2005, 37 (02) :427-441

[10]

GONZALEZGARCIA M, 1994, DEVELOPMENT, V120, P3033

← 1 2 3 4 →