The interactions of adenylate cyclases with P-site inhibitors

被引：81

作者：

Dessauer, CW ^{[1
]}

Tesmer, JJG

Sprang, SR

Gilman, AG

机构：

[1] Univ Texas, Hlth Sci Ctr, Dept Integrat Biol Pharmacol & Physiol, Dallas, TX 75235 USA

[2] Univ Texas, SW Med Ctr, Howard Hughes Med Inst, Dept Pharmacol, Dallas, TX 75235 USA

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 1999年 / 20卷 / 05期

关键词：

D O I：

10.1016/S0165-6147(99)01310-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Recent kinetic, binding and crystallographic studies using P-site inhibitors of mammalian adenylate cyclases provide new insights into the catalytic mechanism of these highly regulated enzymes. Here, Carmen Dessauer and colleagues discuss the conformational states of adenylate cyclase, the structural determinants of inhibitor binding and the potential uses of these inhibitors as pharmacological agents.

引用

页码：205 / 210

页数：6

共 47 条

[1] Artymiuk PJ, 1997, NATURE, V388, P33, DOI 10.1038/40310
[2] Adenylyl cyclase type II is stimulated by PKC via C-terminal phosphorylation
Bol, GF
Hulster, A
Pfeuffer, T
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1997, 1358 (03): : 307 - 313
[3] BUSHFIELD M, 1990, MOL PHARMACOL, V38, P848
[4] Adenylyl cyclase 6 is selectively regulated by protein kinase A phosphorylation in a region involved in G alpha(s), stimulation
Chen, YB
Harry, A
Li, JR
Smit, MJ
Bai, X
Magnusson, R
Pieroni, JP
Weng, GZ
Iyengar, R
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (25) : 14100 - 14104
[5] Adenine nucleoside 3′-tetraphosphates are novel and potent inhibitors of adenylyl cyclases
Désaubry, L
Johnson, RA
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (38) : 24972 - 24977
[6] 2',5'-dideoxyadenosine 3'-polyphosphates are potent inhibitors of adenylyl cyclases
Desaubry, L
Shoshani, I
Johnson, RA
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (05) : 2380 - 2382
[7] Identification of a Giα binding site on type V adenylyl cyclase
Dessauer, CW
Tesmer, JJG
Sprang, SR
Gilman, AG
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (40) : 25831 - 25839
[8] Interactions of forskolin and ATP with the cytosolic domains of mammalian adenylyl cyclase
Dessauer, CW
Scully, TT
Gilman, AG
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (35) : 22272 - 22277
[9] The catalytic mechanism of mammalian adenylyl cyclase - Equilibrium binding and kinetic analysis of P-site inhibition
Dessauer, CW
Gilman, AG
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (44) : 27787 - 27795
[10] Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 Å resolution
Doublié, S
Tabor, S
Long, AM
Richardson, CC
Ellenberger, T
[J]. NATURE, 1998, 391 (6664) : 251 - 258

← 1 2 3 4 5 →