Microbial transformation of glycyrrhetinic acid by Mucor polymorphosporus

被引：50

作者：

Xin, XL

Liu, YF

Ye, M

Guo, HZ

Guo, D

机构：

[1] Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100083, Peoples R China

[2] Beijing Vocat Coll Elect Sci & Technol, Biotechnol Applicat Ctr, Beijing, Peoples R China

来源：

PLANTA MEDICA | 2006年 / 72卷 / 02期

关键词：

microbial transformation; glycyrrhetinic acid; Mucor polymorphosporus; structural identification;

D O I：

10.1055/s-2005-873198

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Glycyrrhetinic acid (GA; 1) is one of the major constituents of a traditional Chinese medicine, the roots of Glycyrrhiza uralensis, called Gancao in Chinese. In the present paper, the biotransformation of GA by Mucor polymorphosporus (AS 3.3443) was investigated and eight metabolites were obtained. Based on their chemical and spectral data, the structures of the derivatives were respectively elucidated as 24-hydroxyglycyrrhetinic acid (2), 6 beta-hydroxyglycyrrhetinic acid (3), 7 alpha-hydroxyglycyrrhetinic acid (4), 7 beta-hydroxyglycyrrhetinic acid (5), 3-0-acetyl-7 beta-hydroxyglycyrrhetinic acid (6), 3-oxo-7 beta-liydroxyglycyrrhetinic acid (7), 15 alpha-hydroxyglycyrrhetinic acid (8), 3-oxo-15 alpha-hydroxyglycyrrhetinic acid (9), among which metabolites 3, 4, 6, 7 and 9 are new compounds.

引用

页码：156 / 161

页数：6

共 11 条

[1]

Abourashed EA, 1999, CURR MED CHEM, V6, P359

[2]

METABOLISM OF GLYCYRRHETIC ACID BY RAT-LIVER MICROSOMES .2. 22 ALPHA-HYDROXYLATION AND 24-HYDROXYLATION [J].