Interneuron Diversity series:: Interneuronal neuropeptides -: endogenous regulators of neuronal excitability

被引:142
作者
Baraban, SC
Tallent, MK [1 ]
机构
[1] Drexel Univ, Coll Med, Dept Physiol & Pharmacol, Philadelphia, PA 19102 USA
[2] Univ Calif San Francisco, Dept Neurol Surg, San Francisco, CA 94143 USA
[3] Univ Calif San Francisco, PIBS Grad Program Neurosci, San Francisco, CA 94143 USA
关键词
D O I
10.1016/j.tins.2004.01.008
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Interneurons are often classified according to neuropeptide content. However, it is becoming increasingly clear that neuropeptides are more than convenient neurochemical markers and can act as important modulators of neuronal activity. Recent advances in understanding neuropeptide release and physiological actions suggest that the interneuronal system of neuropeptides; is crucial for maintaining appropriate brain function under normal and pathophysiological conditions. In particular, interneuronal neuropeptides appear to play roles in cognition and as endogenous anti-epileptic agents. This article describes current understanding of the conditions under which neuropeptides are released from interneurons, their specific effects on neuronal excitability and synaptic transmission, and the consequences of their loss of function.
引用
收藏
页码:135 / 142
页数:8
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