Two new furanoditerpenes from Saururus chinenesis and their effects on the activation of peroxisome proliferator-activated receptor γ

被引：55

作者：

Hwang, BY ^{[1
]}

Lee, JH ^{[1
]}

Nam, JB ^{[1
]}

Kim, HS ^{[1
]}

Hong, YS ^{[1
]}

Lee, JJ ^{[1
]}

机构：

[1] Korea Res Inst Biosci & Biotechnol, Anticanc Res Lab, Taejon 305600, South Korea

来源：

JOURNAL OF NATURAL PRODUCTS | 2002年 / 65卷 / 04期

关键词：

D O I：

10.1021/np010440j

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new acyclic furanoditerpene compounds, saurufuran A (1) and B (2), were obtained from the root of Saururus chinensis, and their structures were elucidated by means of 1D and 2D NMR spectroscopic analyses. Saurufuran A (1) is effective on the activation of peroxisome proliferator-activated receptor gamma (PPARgamma) with an EC50 value of 16.7 muM; however, saurufuran B (2), with an EC50 value of > 100 muM weakly activated the PPARgamma.

引用

页码：616 / 617

页数：2

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