Regional Coherence Changes in Alzheimer's Disease Patients with Depressive Symptoms: A Resting-State Functional MRI Study

被引：26

作者：

Guo, Zhongwei ^{[1
,2
,3
]}

Liu, Xiaozheng ^{[4
,5
]}

Jia, Xize ^{[4
,5
]}

Hou, Hongtao ^{[3
]}

Cao, Yulin ^{[3
]}

Wei, Fuquan ^{[3
]}

Li, Jiapeng ^{[3
]}

Chen, Xingli ^{[3
]}

Zhang, Yingchun ^{[1
,2
]}

Shen, Yuedi ^{[6
]}

Wei, Lili ^{[1
,2
]}

Xu, Luoyi ^{[1
,2
]}

Chen, Wei ^{[1
,2
,7
]}

机构：

[1] Zhejiang Univ, Sch Med, Sir Run Run Shaw Hosp, Dept Psychiat, Hangzhou 310016, Zhejiang, Peoples R China

[2] Collaborat Innovat Ctr Brain Sci, Hangzhou 310016, Zhejiang, Peoples R China

[3] Tongde Hosp Zhejiang Provence, Hangzhou, Zhejiang, Peoples R China

[4] Hangzhou Normal Univ, Ctr Cognit Brain Disorders, Hangzhou, Zhejiang, Peoples R China

[5] Zhejiang Key Lab Res Assessment Cognit Impairment, Hangzhou, Zhejiang, Peoples R China

[6] Hangzhou Normal Univ, Affiliated Hosp, Hangzhou, Zhejiang, Peoples R China

[7] Chinese Minist Hlth, Key Lab Med Neurobiol, Hangzhou, Zhejiang, Peoples R China

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2015年 / 48卷 / 03期

关键词：

Alzheimer's disease; depressive symptoms; regional homogeneity; resting state functional magnetic resonance imaging; WHITE-MATTER ABNORMALITIES; LATE-LIFE DEPRESSION; PREFRONTAL CORTEX; MICROSTRUCTURAL ABNORMALITIES; NEUROPSYCHIATRIC SYMPTOMS; RESPONSE-INHIBITION; COGNITIVE DEFICITS; NATIONAL INSTITUTE; MAJOR DEPRESSION; BIPOLAR DISORDER;

D O I：

10.3233/JAD-150460

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Alzheimer's disease (AD) is characterized by progressive cognitive decline along with neuropsychiatric symptoms including depression and psychosis. Depression is a common psychiatric disorder occurring in people across the lifespan. Accumulating evidence indicates that depression may be a prodrome and/or a "risk factor" for AD. However, whether AD and depression share a common pathophysiological pathway is still unclear. The aim of this study was to identify regional alterations in brain function associated with depressive symptoms in mild AD patients. Thirty-two mild AD patients were evaluated using the Neuropsychiatric Inventory and Hamilton Depression Rating Scale, and were divided into two groups: 15 AD patients with depressive symptoms (D-AD) and 17 non-depressed AD (nD-AD) patients. Using the approach of regional homogeneity (ReHo), we characterized resting-state regional brain activity in D-AD and nD-AD patients. Compared with nD-AD patients, D-AD patients showed decreased ReHo in the right precentral gyrus, right superior frontal gyrus, right middle frontal gyrus, and right inferior frontal cortex. Our findings show regional brain activity alterations in D-AD patients. Thus, D-AD pathogenesis may be attributed to abnormal neural activity in multiple brain regions.

引用

页码：603 / 611

页数：9

共 73 条

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