O-GlcNAc cycling: How a single sugar post-translational modification is changing the way we think about signaling networks

被引:136
作者
Slawson, C [1 ]
Housley, MP [1 ]
Hart, GW [1 ]
机构
[1] Johns Hopkins Univ, Sch Med, Dept Biol Chem, Baltimore, MD 21205 USA
关键词
O-GlcNAc; O-GlcNAc transferase; O-GlcNAcase; diabetes; stress; cell cycle; transcription; signaling; phosphorylation;
D O I
10.1002/jcb.20676
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
O-GlcNAc is all ubiquitous post-translational protein modification consisting of a single N-acetlyglucosamine moiety linked to serine or threonine residues on nuclear and cytoplasmic proteins. Recent work has begun to uncover the functional roles of O-GlcNAc in cellular processes. O-GlcNAc modified proteins are involved in sensing the nutrient status of the surrounding cellular environment and adjusting the activity of cellular proteins accordingly. O-GlcNAc regulates cellular responses to hormones such as insulin, initiates a protective response to stress, modulates a cell's capacity to grow and divide, and regulates gene transcription. This review will focus on recent work involving O-GlcNAc in sensing the environment and regulating signaling cascades.
引用
收藏
页码:71 / 83
页数:13
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