Tunable, pulsatile chemical gradient generation via acoustically driven oscillating bubbles

被引：88

作者：

Ahmed, Daniel ^{[1
]}

Chan, Chung Yu ^{[1
]}

Lin, Sz-Chin Steven ^{[1
]}

Muddana, Hari S. ^{[2
]}

Nama, Nitesh ^{[1
]}

Benkovic, Stephen J. ^{[3
]}

Huang, Tony Jun ^{[1
,2
]}

机构：

[1] Penn State Univ, Dept Engn Sci & Mech, University Pk, PA 16802 USA

[2] Penn State Univ, Dept Bioengn, University Pk, PA 16802 USA

[3] Penn State Univ, Dept Chem, University Pk, PA 16802 USA

来源：

LAB ON A CHIP | 2013年 / 13卷 / 03期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

ON-A-CHIP; MICROFLUIDIC CHANNEL; SINGLE; STIMULATION; DIFFERENTIATION; CHEMOTAXIS; RESPONSES; DYNAMICS; CELLS; LAB;

D O I：

10.1039/c2lc40923b

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We present a novel concept of generating both static and pulsatile chemical gradients using acoustically activated bubbles designed in a ladder-like arrangement. Furthermore, by regulating the amplitude of the bubble oscillation, we demonstrate that the chemical gradient profiles can be effectively tuned.

引用

页码：328 / 331

页数：4

共 47 条

[1] A fast microfluidic mixer based on acoustically driven sidewall-trapped microbubbles [J].

Ahmed, Daniel ;

Mao, Xiaole ;

Juluri, Bala Krishna ;

Huang, Tony Jun .

MICROFLUIDICS AND NANOFLUIDICS, 2009, 7 (05) :727-731

[2] A millisecond micromixer via single-bubble-based acoustic streaming [J].

Ahmed, Daniel ;

Mao, Xiaole ;

Shi, Jinjie ;

Juluri, Bala Krishna ;

Huang, Tony Jun .

LAB ON A CHIP, 2009, 9 (18) :2738-2741

[3] A Microfluidic Pipette for Single-Cell Pharmacology [J].

Ainla, Alar ;

Jansson, Erik T. ;

Stepanyants, Natalia ;

Orwar, Owe ;

Jesorka, Aldo .

ANALYTICAL CHEMISTRY, 2010, 82 (11) :4529-4536

[4] Flow photolysis for spatiotemporal stimulation of single cells [J].

Beta, Carsten ;

Wyatt, Danica ;

Rappel, Wouter-Jan ;

Bodenschatz, Eberhard .

ANALYTICAL CHEMISTRY, 2007, 79 (10) :3940-3944

[5] CHEMOTACTIC EFFECT OF MIXTURES OF ANTIBODY AND ANTIGEN ON POLYMORPHONUCLEAR LEUCOCYTES [J].

BOYDEN, S .

JOURNAL OF EXPERIMENTAL MEDICINE, 1962, 115 (03) :453-&

[6] A microfluidic platform for generation of sharp gradients in open-access culture [J].

Cate, David M. ;

Sip, Christopher G. ;

Folch, Albert .

BIOMICROFLUIDICS, 2010, 4 (04)

[7] On-chip manipulation of single microparticles, cells, and organisms using surface acoustic waves [J].

Ding, Xiaoyun ;

Lin, Sz-Chin Steven ;

Kiraly, Brian ;

Yue, Hongjun ;

Li, Sixing ;

Chiang, I-Kao ;

Shi, Jinjie ;

Benkovic, Stephen J. ;

Huang, Tony Jun .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (28) :11105-11109

[8] Lab-on-a-chip: microfluidics in drug discovery [J].

Dittrich, PS ;

Manz, A .

NATURE REVIEWS DRUG DISCOVERY, 2006, 5 (03) :210-218

[9] Concerted stimuli regulating osteo-chondral differentiation from stem cells: phenotype acquisition regulated by microRNAs [J].

Gordeladze, Jan O. ;

Djouad, Farida ;

Brondello, Jean-Marc ;

Noel, Daniele ;

Duroux-Richard, Isabelle ;

Apparailly, Florence ;

Jorgensen, Christian .

ACTA PHARMACOLOGICA SINICA, 2009, 30 (10) :1369-1384

[10] Oscillating bubbles: a versatile tool for lab on a chip applications [J].

Hashmi, Ali ;

Yu, Gan ;

Reilly-Collette, Marina ;

Heiman, Garrett ;

Xu, Jie .

LAB ON A CHIP, 2012, 12 (21) :4216-4227

← 1 2 3 4 5 →