Function and dysfunction of the presenilins

被引:58
作者
Sisodia, SS [1 ]
Kim, SH [1 ]
Thinakaran, G [1 ]
机构
[1] Univ Chicago, Dept Neurobiol Pharmacol & Physiol, Chicago, IL 60637 USA
关键词
D O I
10.1086/302475
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
[No abstract available]
引用
收藏
页码:7 / 12
页数:6
相关论文
共 44 条
[1]  
Baumeister R, 1997, Genes Funct, V1, P149
[2]   Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins [J].
Borchelt, DR ;
Ratovitski, T ;
vanLare, J ;
Lee, MK ;
Gonzales, V ;
Jenkins, NA ;
Copeland, NG ;
Price, DL ;
Sisodia, SS .
NEURON, 1997, 19 (04) :939-945
[3]   A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain [J].
De Strooper, B ;
Annaert, W ;
Cupers, P ;
Saftig, P ;
Craessaerts, K ;
Mumm, JS ;
Schroeter, EH ;
Schrijvers, V ;
Wolfe, MS ;
Ray, WJ ;
Goate, A ;
Kopan, R .
NATURE, 1999, 398 (6727) :518-522
[4]   Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein [J].
De Strooper, B ;
Saftig, P ;
Craessaerts, K ;
Vanderstichele, H ;
Guhde, G ;
Annaert, W ;
Von Figura, K ;
Van Leuven, F .
NATURE, 1998, 391 (6665) :387-390
[5]   Protein topology of presenilin 1 [J].
Doan, A ;
Thinakaran, G ;
Borchelt, DR ;
Slunt, HH ;
Ratovitsky, T ;
Podlisny, M ;
Selkoe, DJ ;
Seeger, M ;
Gandy, SE ;
Price, DL ;
Sisodia, SS .
NEURON, 1996, 17 (05) :1023-1030
[6]   Microglia and the immune pathology of Alzheimer disease [J].
Giulian, D .
AMERICAN JOURNAL OF HUMAN GENETICS, 1999, 65 (01) :13-18
[7]   Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes [J].
Holcomb, L ;
Gordon, MN ;
McGowan, E ;
Yu, X ;
Benkovic, S ;
Jantzen, P ;
Wright, K ;
Saad, I ;
Mueller, R ;
Morgan, D ;
Sanders, S ;
Zehr, C ;
O'Campo, K ;
Hardy, J ;
Prada, CM ;
Eckman, C ;
Younkin, S ;
Hsiao, K ;
Duff, K .
NATURE MEDICINE, 1998, 4 (01) :97-100
[8]  
Kim TW, 1997, J BIOL CHEM, V272, P11006
[9]  
Lah JJ, 1997, J NEUROSCI, V17, P1971
[10]   Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues [J].
Lee, MK ;
Slunt, HH ;
Martin, LJ ;
Thinakaran, G ;
Kim, G ;
Gandy, SE ;
Seeger, M ;
Koo, E ;
Price, DL ;
Sisodia, SS .
JOURNAL OF NEUROSCIENCE, 1996, 16 (23) :7513-7525