Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo

被引：211

作者：

Yamamoto, M

Saijoh, Y

Perea-Gomez, A

Shawlot, W

Behringer, RR

Ang, SL

Hamada, H

Meno, C

机构：

[1] Osaka Univ, Grad Sch Frontier Biosci, Dev Genet Grp, Suita, Osaka 5650871, Japan

[2] Japan Sci & Technol Corp, CREST, Suita, Osaka 5650871, Japan

[3] Univ Strasbourg 1, IGBMC, CNRS, INSERM, F-67404 Illkirch Graffenstaden, France

[4] Univ Texas, MD Anderson Canc Ctr, Dept Mol Genet, Houston, TX 77030 USA

[5] Natl Inst Med Res, Div Dev Neurobiol, London NW7 1AA, England

来源：

NATURE | 2004年 / 428卷 / 6981期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/nature02418

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Patterning of the mouse embryo along the anteroposterior axis during body plan development requires migration of the distal visceral endoderm (DVE) towards the future anterior side by a mechanism that has remained unknown. Here we show that Nodal signalling and the regionalization of its antagonists are required for normal migration of the DVE. Whereas Nodal signalling provides the driving force for DVE migration by stimulating the proliferation of visceral endoderm cells, the antagonists Lefty1 and Cerl determine the direction of migration by asymmetrically inhibiting Nodal activity on the future anterior side.

引用

页码：387 / 392

页数：6

共 32 条

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