Cyclic RGD peptide by ring-closing metathesis

被引：11

作者：

Bijani, C

Varray, S

Lazaro, R

Martinez, J

Lamaty, F

Kieffer, N

机构：

[1] Univ Montpellier 1, CNRS, LAPP, F-34095 Montpellier 5, France

[2] Univ Montpellier 2, CNRS, LAPP, F-34095 Montpellier, France

[3] CRP Sante, CNRS, Lab Franco Luxembourgeois Rech Biomed, Luxembourg, Luxembourg

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 20期

关键词：

D O I：

10.1016/S0040-4039(02)00642-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A cyclic pseudopeptide containing the RGD sequence has been synthesized in high yield by ring-closing metathesis using a Grubbs' catalyst in tetrahydrofuran. Conformational analysis has been correlated to structure modeling and preliminary biological activity as an integrin binding inhibitor has been evaluated. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：3765 / 3767

页数：3

共 22 条

[1]

ARNAOUT MA, 1990, IMMUNOL REV, P114

[2]

BRUGGHE HF, 1994, INT J PEPT PROT RES, V43, P166

[3] SYNTHESIS AND BINDING AFFINITIES OF CYCLIC AND RELATED LINEAR ANALOGS OF CCK8 SELECTIVE FOR CENTRAL RECEPTORS [J].