Proliferation response to interleukin-2 and Jak/Stat activation of T cells immortalized by human T-cell lymphotropic virus type 1 is independent of open reading frame I expression

被引:36
作者
Collins, ND
D'Souza, C
Albrecht, B
Robek, MD
Ratner, L
Ding, W
Green, PL
Lairmore, MD
机构
[1] Ohio State Univ, Dept Vet Biosci, Columbus, OH 43210 USA
[2] Ohio State Univ, Ctr Retrovirus Res, Columbus, OH 43210 USA
[3] Ohio State Univ, Ctr Comprehens Canc, Arthur James Canc Hosp & Res Inst, Columbus, OH 43210 USA
[4] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA
[5] Washington Univ, Sch Med, Dept Pathol, St Louis, MO 63110 USA
[6] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA
关键词
D O I
10.1128/JVI.73.11.9642-9649.1999
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Human T-cell lymphotropic virus type 1 (HTLV-1), a complex retrovirus, encodes a hydrophobic 12-kD protein from pX open reading frame (ORF) I that localizes to cellular endomembranes and contains four minimal SH3 binding motifs (PXXP), We have demonstrated the importance of ORF I expression in the establishment of infection and hypothesize that p12(I) has a role in T-cell activation. In this study, we tested interleukin-2 (IL-2) receptor expression, IL-2-mediated proliferation, and Jak/Stat activation in T-cell lines immortalized with either wild-type or ORF I mutant clones of HTLV-1. All cell lines exhibited typical patterns of T-cell markers and maintained mutation fidelity. No significant differences between cell lines were observed in IL-2 receptor chain (alpha, beta, or gamma(c)) expression, in IL-2-mediated proliferation, or in IL-2-induced phosphorylated forms of Stat3, Stat5, Jak1, or Jak3. The expression of ORF I is more likely to play a role in early HTLV-1 infection, such as in the activation of quiescent T cells in vivo.
引用
收藏
页码:9642 / 9649
页数:8
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