Selective Inhibition of Human Brain Tumor Cells through Multifunctional Quantum-Dot-Based siRNA Delivery

被引：122

作者：

Jung, Jongjin ^{[1
]}

Solanki, Aniruddh ^{[1
]}

Memoli, Kevin A. ^{[1
]}

Kamei, Ken-ichiro ^{[2
]}

Kim, Hiyun ^{[1
]}

Drahl, Michael A. ^{[1
]}

Williams, Lawrence J. ^{[1
]}

Tseng, Hsian-Rong ^{[2
]}

Lee, KiBum ^{[1
]}

机构：

[1] Rutgers State Univ, Dept Chem & Chem Biol, Piscataway, NJ 08854 USA

[2] Univ Calif Los Angeles, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 01期

关键词：

antitumor agents; gene knockdown; nanoparticles; nonviral siRNA delivery; target-specific delivery; IN-VIVO; INTRACELLULAR DELIVERY; LIVING CELLS; NANOPARTICLES; GLIOBLASTOMA; CYTOTOXICITY; NANOCRYSTALS; EXPRESSION; REAGENTS; SYSTEMS;

D O I：

10.1002/anie.200905126

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) More than one Job: Quantum dots (QDs) conjugated with thiol-modified small Interfering RNA (siRNA) were functlonalized with thiol-modlfied RGD and HIV-Tat peptides. These multifunctional QDs were used for the targeted delivery and tracking of siRNA molecules for the knockdown of the EGFRvIII gene, which led to the down-regulation of the PI3K-Akt signaling pathway and the apoptosis of malignant brain cancer cells. © 2010 Wiley-VCH Verlag GmbH &. Co. KGaA.

引用

页码：103 / 107

页数：5

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