Synthesis of oligoadducts of malonic acid C60 and their scavenging effects on hydroxyl radical

被引：39

作者：

Cheng, FY

Yang, XL

Zhu, HS

Sun, J

Liu, Y

机构：

[1] Beijing Inst Technol, Res Ctr Mat Sci, Beijing 100081, Peoples R China

[2] Chinese Acad Sci, State Key Lab Struct Chem Unstable & Stable Speci, Inst Chem, Beijing 100864, Peoples R China

来源：

JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS | 2000年 / 61卷 / 07期

基金：

中国国家自然科学基金;

关键词：

malonic acid C-60; one-pot" synthesis; scavenging activity; hydroxyl radical;

D O I：

10.1016/S0022-3697(99)00353-4

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Seven malonate derivatives of C-60 With different addition number and regiostructure were obtained by the "one-pot" reaction of C-60 with diethyl bromomalonate (1:6) and subsequent separation by silica gel chromatography. The corresponding malonic acid derivatives of Cw were formed by hydrolyzing with NaH and CH3OH. Four of them with different addition number (C-60(*C(COOH)(2))(n), n = 1-4) were selected to study the scavenging effects on hydroxyl radical. It was shown that these water-soluble C-60 derivatives had scavenging activity and the efficiency was dependent on their concentration and addition number. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1145 / 1148

页数：4

共 12 条

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AMES BK, 1982, BIOL MED, P339

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