Aging and neural control of the GI tract V. Aging and gastrointestinal smooth muscle: from signal transduction to contractile proteins

被引：23

作者：

Bitar, KN ^{[1
]}

机构：

[1] Univ Michigan, Sch Med, Div Pediat Gastroenterol, Med Ctr,Dept Pediat, Ann Arbor, MI 48109 USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY | 2003年 / 284卷 / 01期

关键词：

heat shock protein 27; actin; tropomyosin; myosin; phosphatidylinositol; 3-kinase; pp60(src) kinase;

D O I：

10.1152/ajpgi.00264.2002

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The object of this theme is to offer new perspectives on the effect of aging on signal-transduction pathways associated with agonist-induced contraction of smooth muscle cells from the colon. Smooth muscle cells from old rats (32 mo old) exhibit limited cell length distribution and diminished contractility. The observed reduced contractile response may be due to the effect of aging on signal-transduction pathways, especially an inhibition of the tyrosine kinase-Src kinase pathway, a reduced activation of the PKC pathway, and a reduced association of contractile proteins [heat shock protein 27 (HSP27)-tropomyosin, HSP27-actin, actin-myosin]. Levels of HSP27 phosphorylation are also reduced compared with adult rats.

引用

页码：G1 / G7

页数：7

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