Coronary calcification detected by electron-beam computed tomography and myocardial infarction - The Rotterdam Coronary Calcification Study

被引:111
作者
Vliegenthart, R
Oudkerk, M
Song, B
van der Kuip, DAM
Hofman, A
Witteman, JCM
机构
[1] Erasmus MC, Dept Epidemiol & Biostat, NL-3000 DR Rotterdam, Netherlands
[2] Univ Groningen, Univ Groningen Hosp, Dept Radiol, Groningen, Netherlands
[3] Erasmus MC, Dept Radiol, Daniel Hoed Clin, NL-3000 DR Rotterdam, Netherlands
[4] First Univ Hosp Chengdu, Dept Radiol, Chengdu, Peoples R China
关键词
calcium; coronary disease; elderly; epidemiology; myocardial infarction; tomography;
D O I
10.1053/euhj.2002.3240
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aims Available data are insufficient to determine the relation between coronary calcification and coronary events in the general population. We cross-sectionally examined the association between coronary calcification and myocardial infarction in the prospective Rotterdam Coronary Calcification Study. Methods and Results From 1997 onwards, subjects were invited for electron-beam computed tomography scanning to detect coronary calcification. The study was embedded in the population-based Rotterdam Study. Calcifications were quantified in a calcium score according to Agatston's method. Calcium scores were available for 2013 participants with a mean age of 71 years (standard deviation, 5.7 years). A history of myocardial infarction prior to scanning was present in 229 subjects. Compared to subjects in the lowest calcium score category (0-100), the age-adjusted odds ratio for myocardial infarction in subjects in the highest calcium score category (above 2000) was 7.7 (95% confidence interval, 4.1-14.5) for men, and 6.7 (95% confidence interval, 2.4-19.1) for women. Additional adjustment for cardiovascular risk factors only slightly altered the estimates. The association was observed across all age subgroups, i.e. also in subjects of 70 years and older. Conclusion A strong and graded association was found between coronary calcification and myocardial infarction. The association remained at high ages.
引用
收藏
页码:1596 / 1603
页数:8
相关论文
共 30 条
  • [1] QUANTIFICATION OF CORONARY-ARTERY CALCIUM USING ULTRAFAST COMPUTED-TOMOGRAPHY
    AGATSTON, AS
    JANOWITZ, WR
    HILDNER, FJ
    ZUSMER, NR
    VIAMONTE, M
    DETRANO, R
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1990, 15 (04) : 827 - 832
  • [2] *AM DIAB ASS, 2001, DIABETES CARE S1, V24, pS5
  • [3] Prediction of coronary events with electron beam computed tomography
    Arad, Y
    Spadaro, LA
    Goodman, K
    Newstein, D
    Guerci, AD
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2000, 36 (04) : 1253 - 1260
  • [4] Bielak LF, 2000, CIRCULATION, V102, P380
  • [5] Common carotid intima-media thickness and risk of stroke and myocardial infarction - The Rotterdam Study
    Bots, ML
    Hoes, AW
    Koudstaal, PJ
    Hofman, A
    Grobbee, DE
    [J]. CIRCULATION, 1997, 96 (05) : 1432 - 1437
  • [6] Chambless LE, 1997, AM J EPIDEMIOL, V146, P483, DOI 10.1093/oxfordjournals.aje.a009302
  • [7] Criqui M H, 1991, Drugs, V42 Suppl 5, P16
  • [8] Prevalence, determinants, and misclassification of myocardial infarction in the elderly
    deBruyne, MC
    Mosterd, A
    Hoes, AW
    Kors, JA
    Kruijssen, DACM
    vanBemmel, JH
    Hofman, A
    Grobbee, DE
    [J]. EPIDEMIOLOGY, 1997, 8 (05) : 495 - 500
  • [9] Coronary calcium does not accurately predict near-term future coronary events in high-risk adults
    Detrano, RC
    Wong, ND
    Doherty, TM
    Shavelle, RM
    Tang, WY
    Ginzton, LE
    Budoff, MJ
    Narahara, KA
    [J]. CIRCULATION, 1999, 99 (20) : 2633 - 2638
  • [10] Coronary calcium: The good, the bad, and the uncertain
    Doherty, TM
    Detrano, RC
    Mautner, SL
    Mautner, GC
    Shavelle, RM
    [J]. AMERICAN HEART JOURNAL, 1999, 137 (05) : 806 - 814