Centrally administered orexin/hypocretin activates HPA axis in rats

被引：239

作者：

Kuru, M

Ueta, Y

Serino, R

Nakazato, M

Yamamoto, Y

Shibuya, I

Yamashita, H

机构：

[1] Univ Occupat & Environm Hlth, Sch Med, Dept Physiol, Yahatanishi Ku, Kitakyushu, Fukuoka 8078555, Japan

[2] Miyazaki Med Coll, Dept Internal Med 3, Miyazaki 8891692, Japan

来源：

NEUROREPORT | 2000年 / 11卷 / 09期

关键词：

ACTH; corticosterone; hypocretin; orexin; paraventricular nucleus; stress;

D O I：

10.1097/00001756-200006260-00034

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of i.c.v. administration of orexin/hypocretin on plasma ACTH, corticosterone and c-fos mRNA in the paraventricular nucleus (PVN) of the rat were examined. Plasma ACTH levels were markedly increased at 30 min after i.c.v. administration of orexin-A Plasma corticosterone fevers were significantly increased in a dose-related manner 30 min after i.c.v. administration of orexin-A and orexin-B. In situ hybridization histochemistry revealed that the induction of the c-fos mRNA in the parvocellular division of the PVN was increased in a dose-related manner 30 min after i.c.v. administration of orexin-A and orexin-B. These results suggest that central orexin/hypocretin activates hypothalamo-pituitary-adrenal (HPA) axis and may be involved in stress-induced activation of the HPA axis. NeuroReport 11:1977-1980 (C) 2000 Lippincott Williams & Wilkins.

引用

页码：1977 / 1980

页数：4

共 15 条

[1] Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems
Date, Y
Ueta, Y
Yamashita, H
Yamaguchi, H
Matsukura, S
Kangawa, K
Sakurai, T
Yanagisawa, M
Nakazato, M
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (02) : 748 - 753
[2] The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity
De Lecea, L
Kilduff, TS
Peyron, C
Gao, XB
Foye, PE
Danielson, PE
Fukuhara, C
Battenberg, ELF
Gautvik, VT
Bartlett, FS
Frankel, WN
van den Pol, AN
Bloom, FE
Gautvik, KM
Sutcliffe, JG
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (01) : 322 - 327
[3] The effect of the orexins on food intake: comparison with neuropeptide Y, melanin-concentrating hormone and galanin
Edwards, CMB
Abusnana, S
Sunter, D
Murphy, KG
Ghatel, MA
Bloom, SR
[J]. JOURNAL OF ENDOCRINOLOGY, 1999, 160 (03) : R7 - R12
[4] Swimming stress that causes hyperglycemia increases in vivo release of noradrenaline, but not acetylcholine, from the hypothalamus of conscious rats
Gotoh, M
Tajima, T
Suzuki, Y
Ikari, H
Iguchi, A
Kakumu, S
Hirooka, Y
[J]. BRAIN RESEARCH, 1998, 780 (01) : 74 - 79
[5] STRESS-INDUCED ACTIVATION OF CRF AND C-FOS MESSENGER-RNAS IN THE PARAVENTRICULAR NUCLEUS ARE NOT AFFECTED BY SEROTONIN DEPLETION
HARBUZ, MS
CHALMERS, J
DESOUZA, L
LIGHTMAN, SL
[J]. BRAIN RESEARCH, 1993, 609 (1-2) : 167 - 173
[6] Effect of lateral cerebroventricular injection of the appetite-stimulating neuropeptide, orexin and neuropeptide Y, on the various behavioral activities of rats
Ida, T
Nakahara, K
Katayama, T
Murakami, N
Nakazato, M
[J]. BRAIN RESEARCH, 1999, 821 (02) : 526 - 529
[7] Orexins/hypocretins regulate drinking behaviour
Kunii, K
Yamanaka, A
Nambu, T
Matsuzaki, I
Goto, K
Sakurai, T
[J]. BRAIN RESEARCH, 1999, 842 (01) : 256 - 261
[8] Distribution of orexin neurons in the adult rat brain
Nambu, T
Sakurai, T
Mizukami, K
Hosoya, Y
Yanagisawa, M
Goto, K
[J]. BRAIN RESEARCH, 1999, 827 (1-2) : 243 - 260
[9] Paxinos G., 1986, RAT BRAIN STEREOTAXI, Vsecond
[10] Peyron C, 1998, J NEUROSCI, V18, P9996

← 1 2 →