The use of substrate engineering in biohydroxylation

被引：32

作者：

de Raadt, A ^{[1
]}

Griengl, H ^{[1
]}

机构：

[1] Graz Univ Technol, Inst Organ Chem, A-8010 Graz, Austria

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2002年 / 13卷 / 06期

关键词：

D O I：

10.1016/S0958-1669(02)00358-0

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

In the biohydroxylation of nonactivated carbon atoms, substrate engineering has been found to be a very useful and simple means to influence substrate acceptance and the regioselectivity and stereoselectivity of this transformation. Recently, this methodology has been applied to the hydroxylation of a large number of compounds including cycloalkane carboxylic acids, ketones, amines, amides and alcohols.

引用

页码：537 / 542

页数：6

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