Hypotensive Effect of Chamaemelum Nobile Aqueous Extract in Spontaneously Hypertensive Rats

被引：6

作者：

Ali Zeggwagh, Naoufel ^{[1
]}

Moufid, Abderahman ^{[1
]}

Michel, Jean Baptiste ^{[2
]}

Eddouks, Mohamed ^{[1
]}

机构：

[1] UFRPNPE BP, Errachidia, Morocco

[2] INSERM, Fac Med, U460, Paris, France

来源：

CLINICAL AND EXPERIMENTAL HYPERTENSION | 2009年 / 31卷 / 05期

关键词：

systolic blood pressure; diuresis; hypertension; ANGIOTENSIN-CONVERTING ENZYME; CHAMOMILE;

D O I：

10.1080/10641960902825453

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This study aims to evaluate the hypotensive effect of Chamaemelum nobile aqueous extract (CNAE) in spontaneously hypertensive rats (SHRs). Single oral administration of CNAE (140 mg/kg) produced a significant reduction (p < 0.05) in systolic blood pressure (SBP) after 24 h of the administration. Daily oral administration of CNAE (140 mg/kg) during 3 weeks produced a significant reduction in SBP in the day 8 (p < 0.01) of treatment. Furthermore, CNAE produced a significant increase in urinary output and electrolytes excretion (p < 0.01) from the day 8 to the end of treatment. We conclude that CNAE possesses a hypotensive and diuretic effect in SHR.

引用

页码：440 / 450

页数：11

共 28 条

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