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Helicobacter pylori and gastrointestinal tract adenocarcinomas

被引：1408
作者：
Peek, RM
Blaser, MJ
机构：
[1] Vanderbilt Univ, Sch Med, Div Gastroenterol, Nashville, TN 37232 USA
[2] NYU, Sch Med, Dept Med, Harbor Vet Affairs Med Ctr, New York, NY 10016 USA
[3] NYU, Sch Med, Dept Microbiol, Harbor Vet Affairs Med Ctr, New York, NY 10016 USA
来源：
NATURE REVIEWS CANCER | 2002年 / 2卷 / 01期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nrc703
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Although gastric adenocarcinoma is associated with the presence of Helicobacter pylori in the stomach, only a small fraction of colonized individuals develop this common malignancy. H. pylori strain and host genotypes probably influence the risk of carcinogenesis by differentially affecting host inflammatory responses and epithelial-cell physiology. Understanding the host-microbial interactions that lead to neoplasia will improve cancer-targeted therapeutics and diagnostics, and provide mechanistic insights into other malignancies that arise within the context of microbially initiated inflammatory states.
引用
收藏
页码：28 / 37
页数：10
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