Omega-3 fatty acids supplementation in children with autism:: A double-blind randomized, placebo-controlled pilot study

被引:223
作者
Amminger, G. Paul
Berger, Gregor E.
Schaefer, Miriam R.
Klier, Claudia
Friedrich, Max H.
Feucht, Martha
机构
[1] Med Univ Vienna, Dept Child Adolescent Psychiat, A-1090 Vienna, Austria
[2] Univ Melbourne, ORYGEN Res Ctr, Parkville, Vic 3052, Australia
关键词
autism; children; hyperactive behaviors; omega-3 fatty acids; pilot study; randomized controlled trial;
D O I
10.1016/j.biopsych.2006.05.007
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: There is increasing evidence that fatty acid deficiencies or imbalances may contribute to childhood neurodevelopmental disorders. Methods: We conducted a randomized, double-blind, placebo-controlled 6-week pilot trial investigating the effects of 1.5 g/d of omega-3 fatty acids ( .84g/d eicosapentaenoic acid, .7g/d docosabexaenoic acid) supplementation in 13 children (aged 5 to 17 years) with autistic disorders accompanied by severe tantrums, aggression, or self-injurious behavior. The outcome measure was the Aberrant Behavior Checklist (ABC) at 6 weeks. Results. We observed an advantage of omega-3 fatty acids compared with placebo for hyperactivity and stereotypy, each with a large effect size, Repeated-measures ANOVA indicated a trend toward superiority of omega-3 fatty acids over placebo for hyperactivity. No clinically relevant adverse effects were elicited in either group. Conclusions. The results of this study provide preliminary evidence that omega-3 fatty acids maybe an effective effective treatment for children with autism.
引用
收藏
页码:551 / 553
页数:3
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