A much improved synthesis of the siderophore enterobactin

被引：33

作者：

Ramirez, RJA ^{[1
]}

Karamanukyan, L ^{[1
]}

Ortiz, S ^{[1
]}

Gutierrez, CG ^{[1
]}

机构：

[1] CALIF STATE UNIV LOS ANGELES,DEPT CHEM & BIOCHEM,LOS ANGELES,CA 90032

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(96)02452-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enterobactin, the cyclic trimer of N-(2,3-dihydroxybenzoyl)-L-serine has been efficiently prepared. A simple and high yield procedure has been developed for construction of N-protected serine trilactone as the key intermediate: methyl N-trityl-L-serinate and 2,2-dibutyl-1,3,2-dioxastannolane were refluxed in xylene to produce the triolide as the only lactone product in 85% yield. (C) 1997, Elsevier Science Ltd.

引用

页码：749 / 752

页数：4

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