Antioxidative effects of green tea polyphenols on free radical initiated and photosensitized peroxidation of human low density lipoprotein

被引：137

作者：

Liu, ZQ ^{[1
]}

Ma, LP ^{[1
]}

Zhou, B ^{[1
]}

Yang, L ^{[1
]}

Liu, ZL ^{[1
]}

机构：

[1] Lanzhou Univ, Natl Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China

来源：

CHEMISTRY AND PHYSICS OF LIPIDS | 2000年 / 106卷 / 01期

基金：

中国国家自然科学基金;

关键词：

low density lipoprotein; antioxidation; green tea polyphenol; antioxidant synergism;

D O I：

10.1016/S0009-3084(00)00133-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Antioxidative effects of the main polyphenolic components extracted from green tea leaves, i.e. (-)-epicatechin (EC), (-)-epigallocatechin (EGC), (-)-epicatechin gallate (ECG), (-)-epigallocatechin gallate (EGCG) and gallic acid (GA), against free radical initiated peroxidation of human low density lipoprotein (LDL) were studied. The peroxidation was initiated either thermally by a water-soluble initiator 2,2'-azobis(2-amidinopropane hydrochloride) (AAPH), or photochemically by a triplet sensitizer benzophenone (BP). The reaction kinetics was monitored by the uptake of oxygen and the depletion of alpha-tocopherol (TOH) presented in the native LDL. Kinetic analysis of the antioxidation process demonstrates that these green tea polyphenols are effective antioxidants against both AAPH-initiated and BP-photosensitized LDL peroxidation. The antioxidative action of the green tea polyphenols includes trapping the initiating and/or propagating peroxyl radicals with the activity sequence EC > EGCG > ECG > EGC > GA for the AAPH initiated peroxidation, and reducing the alpha-tocopheroxyl radical to regenerate alpha-tocopherol with the activity sequence of ECG > EC > EGCG > EGC > GA and ECG > EGCG > GA > EC > EGC for the AAPH-initiated and BP-photosensitized peroxidations respectively. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：53 / 63

页数：11

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