Improvement in HIV-associated motor slowing after antiretroviral therapy including protease inhibitors

被引：78

作者：

Sacktor, NC

Skolasky, RL

Lyles, RH

Esposito, D

Selnes, OA

McArthur, JC

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21224 USA

[2] Johns Hopkins Univ, Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21287 USA

[3] Emory Univ, Rollins Sch Publ Hlth, Dept Biostat, Atlanta, GA 30322 USA

来源：

JOURNAL OF NEUROVIROLOGY | 2000年 / 6卷 / 01期

关键词：

HIV; grooved pegboard; protease inhibitors;

D O I：

10.3109/13550280009006385

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A study of neuropsychological performance was conducted in 33 HIV+ patients initiating highly active antiretroviral therapy (HAART). Grooved Pegboard (GP) non-dominant hand performance improved in 23/33 (70%) subjects (P=0.002). Among 23 patients with motor slowing (GP non-dominant hand z score < - 1.0) at baseline, 18 (78%) improved on the GP non-dominant hand test after initiating HAART (P=0.001). GP non-dominant hand performance improved longitudinally in HIV+ patients initiating HAART, while matched HIV+ controls not on HAART did not change (P=0.045). Significant improvement in motor performance can occur after HAART in HIV+ patients with impairment.

引用

页码：84 / 88

页数：5

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