学术探索
学术期刊
新闻热点
数据分析
智能评审

Lipoprotein(a): A unique risk factor for cardiovascular disease

被引：76
作者：
Anuurad, Erdembileg
Boffa, Michael B.
Koschinsky, Marlys L.
Berglund, Lars
机构：
[1] Univ Calif Davis, Dept Med, VA No Calif Hlth Care Syst, Med Ctr, Sacramento, CA 95817 USA
[2] Queens Univ, Dept Biochem, Kingston, ON K7L 3N6, Canada
来源：
CLINICS IN LABORATORY MEDICINE | 2006年 / 26卷 / 04期
关键词：
D O I：
10.1016/j.cll.2006.07.002
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Lipoprotein(a) (Lp(a)) is present in humans and primates. It has many properties in common with low-density lipoprotein, but Qcontains a unique protein moiety designated apo(a), which is linked to apolipoprotein B-100 by a single disulfide bond. International standards for Lp(a) measurement and optimized Lp(a) assays insensitive to isoform size are not yet widely available. Lp(a) is a risk factor for coronary artery disease, and smaller size apo(a) is associated with coronary artery disease. The physiologic role of Lp(a) is unknown.
引用
收藏
页码：751 / +
页数：24
相关论文
共 129 条
  • [1] LP(A) LIPOPROTEIN - RELATIONSHIP TO SINKING PRE-BETA LIPOPROTEIN, HYPERLIPOPROTEINEMIA, AND APOLIPOPROTEIN-B
    ALBERS, JJ
    CABANA, VG
    WARNICK, GR
    HAZZARD, WR
    [J]. METABOLISM-CLINICAL AND EXPERIMENTAL, 1975, 24 (09): : 1047 - 1054
  • [2] Lp(a) lipoprotein, vascular disease, and mortality in the elderly
    Ariyo, AA
    Thach, C
    Tracy, R
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (22) : 2108 - 2115
  • [3] Electrophoretic measurement of lipoprotein(a) cholesterol in plasma with and without ultracentrifugation: comparison with an immunoturbidimetric lipoprotein(a) method
    Baudhuin, LM
    Hartman, SJ
    O'Brien, JF
    Meissner, I
    Galen, RS
    Ward, JN
    Hogen, SM
    Branum, EL
    McConnell, JP
    [J]. CLINICAL BIOCHEMISTRY, 2004, 37 (06) : 481 - 488
  • [4] LIPOPROTEIN(A) IN THE ARTERIAL-WALL
    BEISIEGEL, U
    NIENDORF, A
    WOLF, K
    REBLIN, T
    RATH, M
    [J]. EUROPEAN HEART JOURNAL, 1990, 11 : 174 - 183
  • [5] BERG K, 1963, ACTA PATHOL MIC SC, V59, P369
  • [6] Spontaneous atherosclerosis in the proximal aorta of LPA transgenic mice on a normal diet
    Berg, K
    Svindland, A
    Smith, AJ
    Lawn, RM
    Djurovic, S
    Aleström, A
    Aleström, P
    Eliassen, K
    [J]. ATHEROSCLEROSIS, 2002, 163 (01) : 99 - 104
  • [7] Berg K, 1997, CLIN GENET, V52, P254
  • [8] Berglund Lars, 1995, Current Opinion in Lipidology, V6, P48, DOI 10.1097/00041433-199502000-00011
  • [9] Evidence for a role of phospholipid oxidation products in atherogenesis
    Berliner, JA
    Subbanagounder, G
    Leitinger, N
    Watson, AD
    Vora, D
    [J]. TRENDS IN CARDIOVASCULAR MEDICINE, 2001, 11 (3-4) : 142 - 147
  • [10] Elevated plasma lipoprotein(a) and coronary heart disease in men aged 55 years and younger - A prospective study
    Bostom, AG
    Cupples, LA
    Jenner, JL
    Ordovas, JM
    Seman, LJ
    Wilson, PWF
    Schaefer, EJ
    Castelli, WP
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1996, 276 (07): : 544 - 548
12345678910