Beyond TGF-β: a prostaglandin promotes fibrosis

被引：32

作者：

Olman, Mitchell A. ^{[1
,2
]}

机构：

[1] Cleveland Clin Fdn, Lerner Res Inst, Cleveland, OH 44195 USA

[2] Cleveland Clin Fdn, Resp Inst, Cleveland, OH 44195 USA

来源：

NATURE MEDICINE | 2009年 / 15卷 / 12期

关键词：

INDUCED PULMONARY FIBROSIS; MYOFIBROBLAST; FIBROBLASTS; ACTIVATION; RECEPTOR; CATENIN;

D O I：

10.1038/nm1209-1360

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The deposition of excess scar tissue that occurs in lung fibrosis is known to be mediated by transforming growth factor-beta (TGF-beta). Prostaglandin F(2 alpha) and the F prostanoid (FP) receptor are now identified as mediators that act independently of TGF-beta (pages 1426-1430).

引用

页码：1360 / 1361

页数：2

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