Climbing fiber activation of metabotropic glutamate receptors on cerebellar Purkinje neurons

被引：88

作者：

Dzubay, JA

Otis, TS ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Sch Med, Dept Neurobiol, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Sch Med, Brain Res Inst, Los Angeles, CA 90095 USA

来源：

NEURON | 2002年 / 36卷 / 06期

关键词：

D O I：

10.1016/S0896-6273(02)01052-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In the cerebellum, metabotropic glutamate receptors (mGluRs) are required for distinct forms of synaptic plasticity expressed at parallel fiber (PF) and climbing fiber (CF) synapses. At PF synapses, mGluR activation generates a slow synaptic current and triggers intracellular calcium release; at CF synapses, mGluR activation has not been observed. This has led some investigators to propose that mGluR-dependent changes in CF synaptic strength are induced heterosynaptically. Here we describe an mGluR-mediated response to CF stimulation consisting of two parallel signaling pathways: one leading to a slow synaptic conductance and the other leading to internal calcium release. This additional target for glutamate broadens the signaling capabilities of CF synapses and raises the possibility that changes in CF strength are homosynaptically triggered.

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收藏

页码：1159 / 1167

页数：9

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