Correlation between human immunodeficiency virus type 1 RNA levels in the female genital tract and immune activation associated with ulceration of the cervix

被引:52
作者
Lawn, SD
Subbarao, S
Wright, TC
Evans-Strickfaden, T
Ellerbrock, TV
Lennox, JL
Butera, ST
Hart, CE
机构
[1] Ctr Dis Control & Prevent, HIV & Retrovirol Branch, Div AIDS Sexually Transmitted Dis, Atlanta, GA 30333 USA
[2] Ctr Dis Control & Prevent, TB Lab Res, Natl Ctr Infect Dis, Atlanta, GA 30333 USA
[3] Ctr Dis Control & Prevent, Div HIV AIDS Prevent Surveillance & Epidemiol, Natl Ctr HIV STD & TB Prevent, Atlanta, GA 30333 USA
[4] Emory Univ, Sch Med, Dept Med, Atlanta, GA USA
[5] Columbia Univ, Coll Phys & Surg, Dept Pathol, New York, NY USA
基金
英国惠康基金;
关键词
D O I
10.1086/315514
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
To address the hypothesis that local immune activation resulting from genital ulceration enhances human immunodeficiency virus type 1 (HIV-1) replication and shedding into the genital tract, paired plasma and cervicovaginal lavage (CVL) samples were obtained from 12 HIV-infected women before and after treatment of cervical intraepithelial lesions. Two weeks after treatment, inflammation and ulceration of the cervix were accompanied by major increases in mean concentrations of HIV-1 RNA (200-fold), tumor necrosis factor-alpha, interleukin 6, and soluble markers shed by activated lymphocytes and macrophages (sCD25 and sCD14, respectively) in CVL samples (P < .01 for each), but not plasma. Strong temporal and quantitative correlations were observed between concentrations of immunological markers and HIV-1 load in this compartment during a 10-week follow-up, Furthermore, in the presence of genital ulceration, HIV-1 in CVL samples was more readily captured by antibodies directed against virion-associated HLA-DR, a marker of host-cell activation, compared with virus in plasma. We suggest that local immune activation increases HIV-1 load in genital secretions, potentially increasing the risk of HIV-1 transmission.
引用
收藏
页码:1950 / 1956
页数:7
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