Differential effect of corticosterone on spatial learning abilities in apolipoprotein E knockout and C57BL/6J mice

被引：24

作者：

Grootendorst, J ^{[1
]}

Kempes, MM ^{[1
]}

Lucassen, PJ ^{[1
]}

Dalm, S ^{[1
]}

de Kloet, ER ^{[1
]}

Oitzl, MS ^{[1
]}

机构：

[1] Leiden Univ, Med Ctr, Leiden Amsterdam Ctr Drug Res, Div Med Pharmacol, NL-2300 RA Leiden, Netherlands

来源：

BRAIN RESEARCH | 2002年 / 953卷 / 1-2期

关键词：

Alzheimer's disease; hippocampus; spatial learning; glucocorticoid; hypothalamic-pituitary-adrenal axis; apolipoprotein E;

D O I：

10.1016/S0006-8993(02)03399-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Previously, we found that repeated exposure to predator stress corrected the deficit in spatial learning of apolipoprotein E-knockout (apoE0/0) mice, but impaired cognitive performance of wild-type mice. Here we show that elevated corticosterone concentrations, accomplished by subcutaneously implanted pellets, results in similar genotype-related effects on water maze learning: while apoE0/0 mice improved their spatial learning abilities, wild-type mice (C57/B16J) became impaired. These results suggest that corticosterone mediates the lasting effects of environmental challenges on apoE-genotype related cognitive performance. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：281 / 285

页数：5

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