Troponin component of cardiotonic effects of levosimendan on isolated myocardium from patients with chronic heart failure

被引：1

作者：

Afanas'ev, SA ^{[1
]}

Timofeev, VY ^{[1
]}

Karpov, RS ^{[1
]}

机构：

[1] Russian Acad Med Sci, Siberian Div, Tomsk Res Ctr, Inst Cardiol, Tomsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1999年 / 128卷 / 10期

关键词：

levosimendan; cardiotonic action; epinephrine;

D O I：

10.1007/BF02433205

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Experiments on isolated myocardial preparations from patients with coronary heart disease showed that inotropic effects of levosimendan in a dose of 0.73 mu mol/liter were primarily due to activation of cAMP-dependent systems of regulation of cell metabolism. Increased affinity of troponin C for Ca2+ impaired muscle relaxation in patients with chronic heart failure.

引用

页码：1052 / 1053

页数：2

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