Circulating Dickkopf-1 and Radiological Progression in Patients with Early Rheumatoid Arthritis Treated with Etanercept

被引：57

作者：

Garnero, Patrick ^{[1
,2
]}

Tabassi, Nadine Charni-Ben ^{[1
]}

Voorzanger-Rousselot, Nathalie ^{[1
]}

机构：

[1] Synarc, Biochem Markers, F-69003 Lyon, France

[2] INSERM, Res Unit 664, F-69008 Lyon, France

来源：

JOURNAL OF RHEUMATOLOGY | 2008年 / 35卷 / 12期

关键词：

DICKKOPF-1; RHEUMATOID ARTHRITIS; BONE EROSION;

D O I：

10.3899/jrheum.080356

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. Dickkopf-1 (Dkk-1) regulates bone remodeling in animal models of inflammatory arthritis, but its role in patients with rheumatoid arthritis (RA) remains unclear. Methods. Baseline circulating Dkk-1 was measured in 113 patients with RA (< 3 yrs) who received etanercept (10 or 25 mg twice/week, n = 63) or methotrexate alone (n = 40) for I year. Progression was assessed by changes in radiological Sharp score. Results. Increased Dkk-1 was associated with a higher risk of progression of bone erosion, independently of age, sex, baseline radiological damage, C-reactive protein, and disease activity in patients treated with etanercept. Conclusion. Dkk-1 may be an important mediator of bone erosion in patients with RA. (First Release Oct 1 2008; 1 Rheumatol 2008,35:2313-5; doi:10.3899/jrheum.080356)

引用

页码：2313 / 2315

页数：3

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