Recent Progress in the Design of Selectin Inhibitors

被引：13

作者：

Chhabra, Siri Ram ^{[1
]}

Rahim, Aisyah S. Abdul ^{[1
]}

Kellam, Barrie ^{[1
]}

机构：

[1] Univ Nottingham, Sch Pharm, Univ Pk, Nottingham NG7 2RD, England

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2003年 / 3卷 / 07期

关键词：

Selectins; sialyl Lewis(x); adhesion molecules; antagonist; mimetics; inflammation;

D O I：

10.2174/1389557033487791

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The selectins are a family of cell-adhesion proteins that mediate the early stages of leukocyte recruitment from the blood stream to sites of tissue damage through recognition of the carbohydrate epitope sialyl Lewis(x) (sLe(x)). Current development of small molecule based inhibitors of this process and their clinical potential to address numerous acute and chronic diseases are explored.

引用

页码：679 / 687

页数：9

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