Detection of anti-ganglio side antibodies in Guillain-Barre syndrome and its variants by the agglutination assay

被引：22

作者：

Alaedini, A

Briani, C

Wirguin, I

Siciliano, G

D'Avino, C

Latov, N

机构：

[1] Cornell Univ, Dept Neurol & Neurosci, New York, NY 10021 USA

[2] Univ Padua, Dept Neurol & Psychiat Sci, Padua, Italy

[3] Soroka Univ, Med Ctr, Dept Neurol, Beer Sheva, Israel

[4] Univ Pisa, Dept Neurosci, Pisa, Italy

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2002年 / 196卷 / 1-2期

关键词：

Guillain-Barre syndrome; acute inflammatory demyelinating polyneuropathy acute motor axonal neuropathy; acute motor and sensory axonal; neuropathy; Miller Fisher syndrome; ganglioside antibodies;

D O I：

10.1016/S0022-510X(02)00022-9

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Sera from 40 patients with Guillain-Barre syndrome (GBS), including the subtypes acute inflammatory demyelinating polyneuropathy (AIDP), acute motor axonal neuropathy (AMAN), acute motor and sensory axonal neuropathy (AMSAN), and Miller Fisher syndrome (MFS) were examined for the presence of anti-ganglioside antibodies using the ganglioside agglutination assay, and the enzyme-linked immunosorbent assay (ELISA). In the ELISA system, sera were tested for IgM and IgG antibodies to GM 1, GM2, GD1a, GD1b, GT1b, and GQ1b gangliosides. Antibodies to gangliosides were detected in 21 (53%) of the GBS patients by agglutination assay and in 17 (43%) of the patients by ELISA. Some of the sera reacted with more than one ganglioside. Antibodies were not found in the control sera that were studied. The agglutination assay may be useful for rapid screening of GBS sera for antibodies to multiple gangliosides. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：41 / 44

页数：4

共 22 条

[1] Ganglioside agglutination immunoassay for rapid detection of autoantibodies in immune-mediated neuropathy [J].