Autoregulation of blood flow to choroid plexus of rabbits

Blood flow to the choroid plexus (CP) of rabbits was measured before and during an increase in arterial pressure (AP). Blood flow returned to control levels in the CP of the lateral and fourth ventricles of the brain when AP was increased 63% by i.v. infusion of norepinephrine. However, when AP was increased 68% by occlusion of the descending thoracic aorta, blood flow to the CP of the fourth ventricle remained elevated, while blood flow to the CP of the lateral ventricles returned to the control level. Our findings suggest that blood flow to the CP of the lateral ventricles autoregulates during nonpharmacological or pharmacological increases in AP, while blood flow to CP of the fourth ventricle does not autoregulate during nonpharmacological increases in AP. (C) 1997 Elsevier Science B.V.