Lead inhibits type-I iodothyronine 5'-monodeiodinase in the Indian rock pigeon Columba livia: A possible involvement of essential thiol groups

被引：11

作者：

Chaurasia, SS ^{[1
]}

Panda, S ^{[1
]}

Kar, A ^{[1
]}

机构：

[1] DEVI AHILYA UNIV,SCH LIFE SCI,INDORE 452001,INDIA

来源：

JOURNAL OF BIOSCIENCES | 1997年 / 22卷 / 02期

关键词：

lead; type-I iodothyronine 5'-monodeiodinase; thyroxine; 3,3',5-triiodothyronine; glutathione; lipid peroxidation; antioxidant enzymes;

D O I：

10.1007/BF02704737

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A study has been made to reveal the mode of action of lead inhibiting type-I iodothyronine 5'-monodeiodioase (5'-D) activity in the Indian rock pigeon, Columba livia. Administration of lead acetate (6 mg/kg body weight/day) for 20 days decreased 5'-D activity and glutathione content in the Liver and kidney homogenates. It also reduced the serum concentration of 3,3', 5-triiodothyronine (T-3) with a marginal increase in serum thyroxine (T-4). Hepatic and renal lipid peroxidative process increased significantly following lead treatment, whereas the levels of antioxidant enzymes such as superoxide dismutase (SOD) and catalase (CAT) were decreased. The possible involvement of lipid peroxidative process in the inhibition of 5'-D activity in Columba livia is suggested.

引用

页码：247 / 254

页数：8

共 31 条

[1]

Aebi H.E., 1983, Methods of enzymatic analysis, P273, DOI DOI 10.1016/J.REPROTOX.2005.05.003

[2]

BROWN B L, 1970, P569

[3]

CHAURASIA SS, 1995, CURR SCI INDIA, V69, P698

[4] Lead induced thyroid dysfunction and lipid peroxidation in the fish Clarias batrachus with special reference to hepatic type I-5'-monodeiodinase activity [J].