Evaluation of eight commercial tests for Mycoplasma pneumoniae antibodies in the absence of acute infection

被引：69

作者：

Nir-Paz, R ^{[1
]}

Michael-Gayego, A ^{[1
]}

Ron, M ^{[1
]}

Block, C ^{[1
]}

机构：

[1] Hadassah Hebrew Univ Med Ctr, Dept Clin Microbiol & Infect Dis, Jerusalem, Israel

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2006年 / 12卷 / 07期

关键词：

assays; diagnosis; IgG; IgM; Mycoplasma pneumoniae; serology;

D O I：

10.1111/j.1469-0691.2006.01469.x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Eight commercially available tests for Mycoplasma pneumoniae (Serodia-Myco II, Labsystems IgM and IgG EIA, IgM and IgG LISA tests, ImmunoWell IgG test and SeroMP IgM and IgG) were compared using 204 single sera from healthy individuals. IgM peaked in late childhood and then declined, while IgG rose progressively into adulthood. Inter-assay agreement was poor. Positivity in Serodia-Myco II and LISA IgG was associated with blood group or Coombs positivity, suggesting non-specific reactions. The study confirmed that single serum serology is unsuitable for the diagnosis of M. pneumoniae infection, and that commercially available tests need further improvement.

引用

页码：685 / 688

页数：5

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